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| 高效液相色谱法测定血浆中格列吡嗪的浓度 | |
| 引用本文： | 钟明康 陆丛笑. 高效液相色谱法测定血浆中格列吡嗪的浓度[J]. 中国临床药学杂志, 1999, 8(3): 172-174 |
| 作者姓名： | 钟明康 陆丛笑 |
| 作者单位： | 上海医科大学华山医院药剂科 上海200040(钟明康，张静华)，上海医科大学华山医院药剂科 上海200040临床药学进修生(陆丛笑) |
| 摘 要： | 目的：为研究格列吡嗪的药物动力学及其制剂的开发提供方法。方法：采用ＨＰＬＣ法测定血药浓度。结果：该方法在２０￣１０００ｎｇ／ｍｌ浓度范围内有良好的线性关系，方法回收率达１００％，日内，日间变异系数均小于７％，最低检测浓度达１０ｎｇ／ｍｌ，结论：该方法适合于药物动力学研究。 |
| 关 键 词： | 格列吡嗪 HPLC 血药浓度 |
Determination of glipizide in plasma by HPLC |
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| Zhong Mingkang,Zhang Jinghua,Lu Congxiao. Determination of glipizide in plasma by HPLC[J]. Chinese Journal of Clinical Pharmacy, 1999, 8(3): 172-174 | |
| Authors: | Zhong Mingkang Zhang Jinghua Lu Congxiao |
| Affiliation: | Zhong Mingkang,Zhang Jinghua,Lu Congxiao Department of Pharmacy,Huashan Hospi-tal,Shanghai Medical University,Shanghai 200040 |
| Abstract: | AIM:To provide a method for study of glipizide pharmacokinetics and develop-ment of it's products. METHODS: Determination of plasma level by HPLC. RESULTS: Within 20 to 1 000 ng/ml a good linear relationship was gotten between drug level and it's responds, their recoveries of glipizide at different concentrations were near 100% ,within-day and between-day coefficients of variance were less than 7% , and minimum detective concen-tration was 10 ng/ml. CONCLUSION:The method is fit for pharmacokinetics study. |
| Keywords: | glipizide high performance liquid chromatography plasma sample |
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