| 胰岛素鼻腔喷雾剂的大鼠鼻纤毛毒性考察 |
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| 引用本文： | 张奕 蒋新国. 胰岛素鼻腔喷雾剂的大鼠鼻纤毛毒性考察[J]. 中国临床药学杂志, 1999, 8(4): 230-232 |
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| 作者姓名： | 张奕 蒋新国 |
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| 作者单位： | 上海医科大学药学院生物药剂学研究室!上海200032 |
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| 摘 要： | 目的：考察胰岛素鼻腔喷雾剂的鼻纤毛毒性。方法：扫描电镜观察鼻喷雾剂对大卤粘膜表面形态的影响。结果：大鼠给予胰岛素鼻喷雾剂后，扫描电镜观察，其鼻中卫粘膜的纤毛形态与给予生理盐水的对照组无显著差异。结论：上述胰岛素鼻喷雾剂无急性鼻粘膜纤毛毒性。
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| 关 键 词： | 胰岛素 鼻腔给药 鼻纤毛 毒性 大鼠 |
Evaluation of a nasal ciliotoxicity of a nasal insulin spray in rats |
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| Zhang Yi,Jiang Xingguo,Zhang Qizhi. Evaluation of a nasal ciliotoxicity of a nasal insulin spray in rats[J]. Chinese Journal of Clinical Pharmacy, 1999, 8(4): 230-232 |
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| Authors: | Zhang Yi Jiang Xingguo Zhang Qizhi |
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| Abstract: | AIM: To evaluate the nasal ciliotoxicity of a nasal insulin spray. METHODS: The effects of the nasal insulin spray on nasal mucosas of rats were evaluated using electron microscope scanning technique. RESULTS: The electron microscope scanning results showed there were no significant histological differences between the nasal mucosas after application of the nasal insulin spray and saline respectively. CONCLUSION : This nasal insulin spray has no damage to the nasal mucosas of rats. |
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| Keywords: | insulin nasal administration nasal ciliotoxicity |
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