| 川芎嗪对围术期肝脏缺血—再灌注损伤的防治作用 |
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| 引用本文： | 林丽娜 王万铁. 川芎嗪对围术期肝脏缺血—再灌注损伤的防治作用[J]. 中国临床药学杂志, 1999, 8(4): 199-201 |
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| 作者姓名： | 林丽娜 王万铁 |
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| 作者单位： | [1]温州医学院附属第一医院麻醉科 [2]温州医学院病理生理学教研室 |
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| 基金项目： | 浙江省教委科研基金资助课题(951118) |
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| 摘 要： | 目的：探讨川芎嗪对围术期肝脏缺血－再灌注损伤（ＨＩＲＩ）的防治作用。方法：观察１８例肝癌患者手术过程中血中ＧＰＴ、ＳＯＤ、ＧＳＨ－ＰＸ、ＸＯ活性及ＭＤＡ含量的动态变化及川芎嗪的影响。结果：川芎嗪组与对照组比较，ＳＯＤ和ＧＸＨ－ＰＸ活性明显增高（Ｐ〈０．０５和Ｐ〈０．０１），ＭＤＡ含量及ＧＰＴ值显著下降（均Ｐ〈０．０１）。结论：川芎秦上脏围术期ＨＩＲＩ有明显的防护作用。
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| 关 键 词： | 川芎嗪 再灌注损伤 氧自由基 肝脏缺血 |
Protective effect of ligustrazin on hepatic ischemia-reperfusion injury in patients undergoing liver surgery |
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| Lin Lina . Wang Wantie. Xu Zhengjie,et al. Protective effect of ligustrazin on hepatic ischemia-reperfusion injury in patients undergoing liver surgery[J]. Chinese Journal of Clinical Pharmacy, 1999, 8(4): 199-201 |
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| Authors: | Lin Lina . Wang Wantie. Xu Zhengjie et al |
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| Abstract: | AIM: To investigate the protective effects of ligustrazin (LGT) on hepatic is-chemia-reperfusion injury (HIRI ) in patients undergoing liver surgery. METHODS: Changes of the several parameters and effects of LGT on them were observed during HIRI in 18 patients who were scheduled for selective hepatic surgery, parameters of which included glutamate pyruvate transaminase (GPT), superoxide dismutase (SOD), xanthine oxidase (XO), glutathione peroxidase (GSH-PX) and malondialdehyde (MDA). RESULTS: The group protected with LGT, as compared with control group, showed that SOD, GSH-PX activities in plasma all increased significantly and very significantly (P<0. 05 and P<0.01); while GPT, MDA values in plasma all decreased remarkably (all P<0. 01). CONCLUSION; LGT shows notable protective effects on HIRI in patients undergoing liver surgery. |
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| Keywords: | ligustrazin liver ischemia-reperfusion injury oxygen free radicals |
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