46例老年死亡与用药的相关分析

目的：对药物不良反应监测期间所发生的４６例老年死亡病例进行用药相关分析。方法：由ＡＤＲ小组讨论和Ｎａｒａｎｊｏ表评分确定ＡＤＲ后，将死亡时伴发严重ＡＤＲ的病例定为与用药拟相关死亡。结果：４６例死亡病例中，有２７例共发生４３次ＡＤＲ，其中１１例为用药拟相关的死亡，主要为抗菌药物导致为肝，肾功能严重损害及不可控制的二重感染，地高辛中毒导致的严重心律失常。

Drug-related death in 46 the aged

AIM:To study the relationship between death and drug use in 46 elderly death cases occurring in the period of ADR surveillance. METHODS: ADR were judged by hospital ADR monitoring group according to Naranjo scale and the death cases with serious ADR were verified as drug-related death. RESULTS: Of 46 patients, 43 ADR occurred in 27 pa-tients and 11 cases were verified as drug-related deaths (incidence 23. 91 %, 11/46) .mainly serious liver and renal function injury and superinfection induced by antibacterial agents andserious arrhythmia induced by digitalis toxicity. The incidence of ADR in death cases was 58. 70% (27/46). The number of antibacterial agents was positively related to the incidence of ADR while digoxin intoxication related to impaired renal function with aging and to concur-rent drug uses as well. CONCLUSION:Our results suggest that some death cases may be re-lated to unreasonable drug uses.