| GEMFIBROZIL INDUCED MYOSITIS：A CASE REPORT WITH LIGHT MICROSCOPIC AND ULTRASTRUCTURAL STUDY |
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| 作者姓名： | LouisTsun-cheungChow MRCPath FRCPA，FACA Wing-hingChow MRCP |
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| 作者单位： | [1]InstituteofPathology,QueenElizabethHospital,HongKong [2]DepartmentofMedicine,GranthanHospital,Alerdeen,HongKong. |
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| 摘 要： | A 49-year-old woman with chronic renal failure was given gemfibrozil flr hyperlipdemia.She developed gemfibrozil-induced myositis which precipitated an acute compartment syndrome,necessitating emergency fascioto-my.The muscle biopsy showed prominent degeneration of the skeletal muscle fibers,associated with moderate chronic inflammatory infiltration.Electron microscopy revealed myofibrillary fragmentation and mitochondrial disorganization.The clinicopathologic features of gemfibrozil-induced myositis appear to be distinct from those of clofibrate-induced muscular syndrome.Extreme caution should be exercised in the use of gemfibrozil in patients with impaired renmal function.
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| 关 键 词： | gemfibrozil 肌肉综合症 药物治疗 药物不良反应 肌炎 |
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