| 急性戊型肝炎患者血清病毒抗原检测的临床意义 |
| |
| 引用本文： | 郝娃,赵晨燕,李卓,严艳,牛京勤,殷继明,王佑春. 急性戊型肝炎患者血清病毒抗原检测的临床意义[J]. 中国误诊学杂志, 2009, 9(18): 4285-4286 |
| |
| 作者姓名： | 郝娃 赵晨燕 李卓 严艳 牛京勤 殷继明 王佑春 |
| |
| 作者单位： | 1. 首都医科大学附属北京佑安医院,北京市卫生局肝炎研究所,100069
2. 中国药品生物制品检定所细胞室,100050 |
| |
| 基金项目： | 国家高技术研究发展计划(863计划) |
| |
| 摘 要： | 目的：探讨戊型肝炎抗原诊断试剂在临床诊断戊型肝炎病毒感染中的作用。方法：应用酶联免疫吸附试验方法检测戊型肝炎病毒抗原（HEV-Ag）试剂,对387例急性戊型肝炎患者血清标本进行检测,同时进行HEV RNA、抗HEV-IgM、抗HEV-IgG检测。结果：387例急性戊型肝炎患者血清HEV-Ag 140例（36.18%）阳性;单纯抗HEV-IgM阳性组的HEV-Ag阳性率最高;12例患者早期血清HEV-Ag阳性,随访过程中抗HEV-IgM与抗HEV-IgG阳转。结论：通过HEV-Ag检测,可以提高戊型肝炎病毒感染的诊断水平。
|
| 关 键 词： | 肝炎,戊型/诊断 肝炎病毒,戊型/免疫学 肝炎抗原/分析 急性病 人类 |
Detection of HEV Antigen in Patients with Acute Hepatitis E Infection |
| |
| Affiliation: | HAO Wa,ZHAO Chen-yan,LI Zhuo,et al. (Institute of Hepatitis, Beijing Municipal Health Bureau, Beijing 100069, China) |
| |
| Abstract: | Objective：To discuss the clinical significance with using the diagnostic reagent of HEV-Ag. Methods： Three hundred and eighty seven sera from the patients with acute hepatitis E were detected by enzyme immunoassay （ELISA） for HEV-Ag,anti-HEV IgM and IgG and real time fluorescent RT-PCR for HEVRNA. Results：The serum samples from 140（36. 18;）of 387 patients were positive for HEV-Ag. Sera of anti-HEV lgM positive alone were the highest positive rate of HEV-Ag. 12 patients were positive for HEV-Ag and HEV-RNA in the early time of infection. Conclusion：Detection of HEV-Ag can raise the early diagnosis of HEV. |
| |
| Keywords: | Hepatitis E/diagnosis ； Hepatitis E virus/immunology； Hepatitis Antigens/analysis ； Acute Disease ； Humans |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
