动态血压评价不同时间服用氨氯地平的降压效应

目的：研究服药时间对氨氯地平降压效应的影响。方法：采用随机、开放、自身对照的研究方法。高血压患者经二周安慰剂导入期，服安慰剂末诊室血压在９５￣１１５ｍｍＨｇ者入选，随机于７：００或２１：００予５ｍｇ氨氯地平治疗，二周后降压不满意者加至１０ｍｇ，服用氨氯地平六周后，交换服药时间再服六周。服安慰剂末、早晨给药六周、睡前给药六周后分别行动态血压监测，分析其Ｔ／Ｐ、收缩压峰值，舒张压峰值，夜间收缩压和舒张

Effect of 24 h Blood Pressure by Amlodipine Administered in ;Different Time

Objective:To assess the impact of timing administration of amlodipine on antihypertensive effect of amlodipine. Methods:Thirty one outpatients with mild to moderate hypertension after two weeks placebo were randomly received 5 mg amlodipine at 7:00 or at 21:00. Clinic sitting position blood pressure was measured every two weeks. If diastolic blood pressure was not reduced to normal level at 2 weeks of therapy, the dose was increased to 10 mg. After 6 weeks, the time of drug administration was crossed over. Ambulatory blood pressure monitoring(ABPM) was performed after two weeks of placebo, sixth weeks of morning time administration and sixth weeks of night time administration. Results:Clinic blood pressure was lower under both regimes( P< 0 01). Twenty four hour mean, daytime and night time mean, twenty four hour BP load, daytime and night time BP loads, twenty four hour BP peak value were lower under both doses than they were with placebo with little differences. Nocturnal fall of SBP and DBP percentage,daytime and night time HR means did not differ in ABPM. Conclusions:Both morning time and night time administration of amlodipine can control 24 hour blood pressure effectively. This study indicates that timing of administration does not influence the antihypertensive effect of amlodipine.