| 哇巴因抗体对肾血管性高血压大鼠的降压作用 |
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| 引用本文： | 原卫清 曹永孝. 哇巴因抗体对肾血管性高血压大鼠的降压作用[J]. 高血压杂志, 2000, 8(1): 79-81 |
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| 作者姓名： | 原卫清 曹永孝 |
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| 作者单位： | [1]西安医科大学第一附属医院心内科 [2]西安医科大学药学院药理教研室 |
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| 基金项目： | 国家医药技术创新博士项目!（98－B－07），陕西省科技研究发展计划项目!（96K12－G8） |
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| 摘 要： | 目的：探讨哇巴因抗体的降压作用及内源性哇巴因与高血压发病的关系。方法：给”一肾一夹（１Ｋ１Ｃ）“”两肾一夹＋盐（２Ｋ１Ｃ－ｓａｌｔ）”肾血性高血压大鼠随机静注哇巴因抗体、硝普钠、正常兔免疫球蛋白（ＩｇＧ）及生理盐水，颈动脉插管观察注射生３小时内大鼠血压的动态变化。结果：哇巴因抗体对“一肾一夹”、“两肾一夹＋盐”型高血压大鼠具有明显的降压作用，而对“两肾一夹”高血压鼠降压作用不明显。正常免免疫球蛋白
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| 关 键 词： | 哇巴因 抗体 肾血管性 高血压 治疗 |
Effects of Ouabain Antibody on the Blood Pressure in Renovascular Hypertensive Rats |
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| YUAN Weiqing,LU Zhuoren,WANG Hao,CAO Yongxiao,LIU Jing. Effects of Ouabain Antibody on the Blood Pressure in Renovascular Hypertensive Rats[J]. Chinese Journal of Hypertension, 2000, 8(1): 79-81 |
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| Authors: | YUAN Weiqing LU Zhuoren WANG Hao CAO Yongxiao LIU Jing |
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| Abstract: | Aim:To explore the effects of ouabain antibody on the blood pressure in renovascular hypertensive rats and the relationship between endogenous ouabain (EO) and the development of hypertension. Methods: The rats of 1K1C, 2K1C-salt and 2K1C were injected randomly with ouabain antibody, normal rabbit IgG, normal sodium or sodium nitroprusside. The blood pressure of all rats was recorded for 3 h after administration. Results:The ouabain antibody could significantly decrease the blood pressure of rats with 1K1C and 2K1C-salt (P<0. 01 ), but little change in blood pressure was found in 2K1C rats. The normal rabbit IgG didn't decrease blood pressure in any renovascular hypertensive models. Conclusions: The results showed that ouabain antibody may play a role in decreasing blood pressure and indicated that EO might be one of the pathogenesis factors of hypertension. |
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| Keywords: | ouabain antibody hypertensive rats |
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