| 高脂喂养大鼠血清瘦素水平与肝脏瘦素受体mRNA的表达 |
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| 引用本文： | 张德利,刘正娟,李永昕,郎会利,蒋英姿. 高脂喂养大鼠血清瘦素水平与肝脏瘦素受体mRNA的表达[J]. 中华内分泌代谢杂志, 2005, 21(3): 273-274 |
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| 作者姓名： | 张德利 刘正娟 李永昕 郎会利 蒋英姿 |
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| 作者单位： | 1. 浙江宁波市第一医院儿科
2. 辽宁大连医科大学第二附属医院儿科 |
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| 基金项目： | 辽宁省自然科学基金资助项目(9910500206)，笹川奖学金(079) |
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| 摘 要： | 与正常大鼠相比,肥胖大鼠血清瘦素升高(P<0.05),而肝内瘦素受体mRNA表达降低(P<0.05),两者呈负相关(r=-0.823, -0.827,均P<0.05),提示肥胖大鼠高血清瘦素对瘦素受体mRNA表达有抑制作用。
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| 关 键 词： | 高脂饮食 大鼠 Sprague-Dawley 瘦素 受体 瘦素 杂交 原位 |
| 修稿时间： | 2003-11-05 |
The relationship between expressions of OB-Ra and OB-Rb mRNA in liver and serum leptin level in SD rats fed with high fat diet |
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| ZHANG De-Li,LIU Zheng-juan,LI Yong-xin,LANG Hui-li,JIANG Ying-zi. The relationship between expressions of OB-Ra and OB-Rb mRNA in liver and serum leptin level in SD rats fed with high fat diet[J]. Chinese Journal of Endocrinology and Metabolism, 2005, 21(3): 273-274 |
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| Authors: | ZHANG De-Li LIU Zheng-juan LI Yong-xin LANG Hui-li JIANG Ying-zi |
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| Abstract: | Compared with the controls, serum leptin level was elevated in obese rats fed with high fat diet (P<0.05) and the expression of OB-Rb mRNA in liver of obese rats was decreased (P<0.01). There was a significant negative correlation between serum leptin concentration and expressions of OB-Ra, OB-Rb mRNA in obese rats (both P<0.05), suggesting that elevated leptin inhibits expressions of OB-Ra and OB-Rb mRNA in liver of obese rats. |
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| Keywords: | High-fat diet Rats Sprague-Dawley Leptin Receptor leptin In situ hybridization |
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