体外受精-胚胎移植术后妊娠结局回顾性分析

目的:探讨体外受精-胚胎移植术后的妊娠结局。方法:回顾性分析在本生殖医学中心行体外受精-胚胎移植术、单精子卵胞浆内注射术、冻融胚胎移植术后306个妊娠周期的结局及围产儿情况,并与自然受孕妇女进行比较。结果:在306个妊娠周期中,生化妊娠11个周期,临床妊娠295个周期,流产53个周期,宫外孕10个周期,宫内外同时妊娠5个周期。共有168例分娩,与同期在我院自然妊娠分娩的6 203例相比,多胎率(34.52％vs 0.77％)、早产率(33.33％vs 4.56％)有显著性差异(P<0.05)。助孕出生的231例新生儿与自然分娩的6 186比,低体重儿率(37.23％vs 3.30％)、新生儿死亡率(0.87％vs 0.21％)、新生儿畸形率(2.16％vs 4.24％)、死胎率(1.70％vs 0.27％)均有有显著性差异(P<0.05)。另两组在前置胎盘和产后出血方面,差异也有显著性。结论:辅助生育其并发症显著高于自然妊娠。

Comparison between Pregnanct Outcome of IVF-ET and Natural Pregnancies

Objective:To evaluate outcome of pregnancies after in vitro fertilization and embryo transfer (IVF ET). Methods:A retrospective study of 306 IVF-ET, intracytoplasmic sperm injection (ICSI) and frozen thawed embryo transfer (FET) pregnancies was performed, compared the obstetrical outcome and perinatal situation of assisted reproductive treatment pregnancies with that of natural pregnancies. Results:A total of 306 women conceived. There were 11 cases with biochemical pregnancies, 295 cases clinic pregnan cies, 53(17. 96%) cases abortion, 10(3. 4%) cases ectopic pregnancies, 5(1. 7%) cases heterotopic combined with uterine pregnancies. Among a total of 168 deliveries, there were 58(34. 5%) cases with multiple pregnancies, 56(33. 33%) cases premature birth, 55 cases ongoing pregnancies and 9(2. 94%) cases lost follow up. Among a total of 231 neonatal birth, there were 86(37. 23%) cases of low birth weight ,2 (0. 87%) cases neonatal death, 5(2.16%) cases congenital malformation and 4(1.70%) cases fetal death. In the same period,a total of 6 203 women deliveried after natural pregnancy. There were 48(0. 77%) cases with multiple pregnancies, 283(4. 56%) cases premature birth. Among a total of 6 186 neonatal birth, there were 204(3. 30%) cases of low birth weight, 13(0. 21%) cases neonatal death, 262(4. 24%) cases congenital malformation and 17(0. 27%) cases fetal death. There were significant differences in the incidence of multiple pregnancies, premature birth, placenta previa, postpartum hemorrhage, low birth weight, fetal death and neonatal death between pregnancies after assisted reproductive treatment and natural pregnancy (P<0. 05). Conclusion:The incidence of complications were significantly higher in pregnancies after assisted reproductive treatment.