Biological activities of Prunella vulgaris extract |
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Authors: | Psotová Jitka Kolár Milan Sousek Jaromír Svagera Zdenek Vicar Jaroslav Ulrichová Jitka |
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Affiliation: | Institute of Medical Chemistry and Biochemistry, Palacky University, Olomouc, Czech Republic. psotova@tunw.upol.cz |
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Abstract: | The organic fraction (OF; 25.7% w/w of rosmarinic acid) of Prunella vulgaris (total extract) was found to exhibit the following: scavenging activity on diphenylpicrylhydrazyl radical (DPPH), inhibition of in vitro human LDL Cu(II)-mediated oxidation, protection of rat mitochondria and rat hepatocytes exposed to either tert-butyl hydroperoxide, or to Cu(II) and Fe(III) ions. OF also showed a potential to inhibit rat erythrocyte haemolysis and it reduced the production of LTB(4) in bovine PMNL generated by the 5-lipoxygenase pathway. Other observations included antiproliferative effects against HaCaT cells and mouse epidermal fibroblasts and a moderate OF antimicrobial activity on gram-positive bacteria. Rosmarinic, caffeic and 3-(3,4-dihydroxyphenyl)lactic acids exhibited less potent activity than the plant extract in all bioassays. The antioxidative, antimicrobial, together with antiviral effects offer good prospects for the medicinal applications of P. vulgaris. |
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Keywords: | Prunella vulgaris organic fraction phenolic acids DPPH radical assay metal‐ion complexes low‐density lipoprotein cytoprotectivity antiproliferative antimicrobial activity |
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