几丁糖预防硅凝胶乳房假体包膜挛缩的实验研究

目的　探讨几丁糖预防硅凝胶乳房假体置入术后包膜挛缩的效果。方法　以 18只雌性SD大白鼠为实验对象 ,随机分为 3组。于大白鼠两侧背阔肌下各置入小型模拟硅凝胶假体。左侧为实验组 ,剥离腔内注入几丁糖 ,右侧为对照组。术后 4、8、12周分组切取包膜行组织学检查 ,测量其厚度和Ⅰ、Ⅲ型胶原的面密度。结果　实验侧与对照侧包膜结构相似 ,可分为致密层和疏松层两层结构。术后 4周 ,实验侧包膜全层厚度、致密层厚度均小于对照侧 (P <0 .0 1) ,Ⅰ型、Ⅲ型胶原的面密度均低于对照侧 (P <0.0 1)。术后 8、12周 ,实验侧包膜全层厚度、致密层厚度均小于对照侧(P <0.0 5 ) ,Ⅰ型胶原的面密度低于对照侧 (P <0 0 5 ) ,Ⅲ型胶原的面密度与对照侧无差异 (P >0.0 5 )。结论　几丁糖可明显预防硅凝胶乳房假体置入术后的早期包膜挛缩

Preventive effect of chitosan on capsular contracture after implantation of silicone gel-filled mammary implants in Rats

Objective To study the preventive effect of chitosan on capsular contracture after implantation of silicone gel-filled mammary implants in rats. Methods 18 SD female rats were divided into three groups randomly.Small silicone gel-filled mammary implants were implanted under each side of latissimus dorsi muscle.Chitosan was injected into left cavities as experimental sides,and nothing was injected into right cavities as control sides.4,8 and 12 weeks postoperation, specimens were dissected and observed using light microscope,and area density of collagen both type I and type III were also detected. Results Fibrous capsules around implants consist of two layers:dense layer and loose layer.4 weeks postoperation,total thickness of the experimental sides was less than that of the control sides (P<0.01).Area density of collagen either type I or type III of the experimental sides was lower than that of the control sides (P<0.01).Both 8 and 12 weeks postoperation, total thickness of the experimental sides was less than that of the control sides (P<0.05).Area density of collagen type I of the experimental sides was lower than that of the control sides (P<0.05).Area density of collagen type III was of no statistical difference between the experimental sides and the control sides (P>0.05). Conclusions Chitosan can remarkably prevent capsule contracture during the early period after implantation of silicone gel-filled mammary implants.;