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Role of HSP-90 for increased nNOS-mediated vasodilation in mesenteric arteries in portal hypertension |
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| Authors: | Lukas Moleda Lars Jurzik Matthias Froh Erwin Gbele Claus Hellerbrand Rainer H Straub Jürgen Schlmerich Reiner Wiest |
| Affiliation: | Department of Internal Medicine I, University Medical Center, D-93042 Regensburg, Germany |
| Abstract: | AIM:To explore the role of heat shock protein-90 (HSP-90) for nitrergic vasorelaxation in the splanchnic circulation in rats with and without portal hypertension. METHODS: Neuronal nitric oxide synthase (nNOS) and HSP-90 were analyzed by immunofluorescence, western blotting and co-immunoprecipitation in the mesenteric vasculature and isolated nerves of portal-vein-ligated (PVL) rats and sham operated rats. In vitro perfused de-endothelialized mesenteric arterial vasculature was preconstricted with norepinep... |
| Keywords: | Heat shock protein-90 Nitric oxide Vasodilation Portal hypertension Mesenteric circulation |
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