Developments in the measurement of plasma total homocysteine |
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| Authors: | Powers H J Moat S J |
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| Affiliation: | The Centre for Human Nutrition, Division of Clinical Sciences, University of Sheffield, Sheffield, UK. h.j.powers@sheffield.ac.uk |
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| Abstract: | Elevated plasma homocysteine is considered to be a graded risk factor for cardiovascular disease, and for this reason there is great interest in high-performance analytical techniques. Methods have evolved from ion-exchange chromatography to embrace high-performance liquid chromatography with fluorescence or electrochemical detection, immunoassays, gas chromatography-mass spectroscopy and liquid chromatography with tandem mass spectrometry. Immunoassays and high-performance liquid chromatography methods are currently available in kit form, fluorescence polarization immunoassay showing the best performance. |
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