胃癌患者血清VEGF、MMP-2的表达及其与浸润和转移的关系

目的]探讨胃癌患者血清VEGF及MMP-2的表达与胃癌浸润和转移的关系。方法]应用ELISA法检测69例胃癌患者血清VEGF、MMP-2的表达水平，并分析其与临床病理因素间的关系。结果]低分化胃癌患者血清VEGF阳性率（64．0％）显著高于高、中分化者（36．8％，P〈0．05）；且VEGF、MMP-2表达与肿瘤的浸润深度、淋巴结转移、远处转移及TNM分期均密切相关（P〈0．05）。胃癌患者血清VEGF的阳性表达与MMP-2的阳性表达呈正相关（rs=0．322，P〈0．01）。结论]VEGF和MMP-2在胃癌的浸润和转移中起重要作用，血清VEGF、MMP-2的表达水平可作为了解胃癌生物掌行为和判断顸后的指标．

Expression of Serum VEGF and MMP-2 in Gastric Carcinoma and its Relationship with Invasion and Metastasis

Purpose] To investigate the relationship of VEGF and MMP-2 expression with invasion and metastasis in gastric carcinoma. Method] Expression of VEGF and MMP-2 in 69 cases with gastric carcinoma was detected by ELISA method and its relationship with clinical pathological factor was an-alyzed. Results] Serum VEGF positive expression rate in low differentiation patients (64.0% ) was significantly higher than that in morderate, high differentiation patients (36.8%)(P<0.05). Serum VEGF and MMP-2 expression level was significantly associated with depth of invasion, lymph node metastasis, distant metastasis and TNM stage(P<0.05). Positive correlation was found between the posi-tive expression of serum VEGF and MMP-2(rs=0.322,P<0.01). Conclusion] VEGF and MMP-2 play important role in invasion and metastasis of gastric carcinoma. The expression level of serum VEGF and MMP-2 is helpful for evaluation of the biological behavior and prognosis of gastric carcinoma.