有氧运动对慢性心力衰竭患者心肌损伤及血浆CGRP和ET-1的影响

目的探讨老年慢性心力衰竭患者有氧运动训练前后血浆内皮缩血管肽（ET-1）和降钙素基因相关肽（CGRP）变化及其与心肌损伤的关系。方法38例NYHA心功能Ⅱ～Ⅲ级的老年住院患者,在常规药物治疗基础上分为对照组18例,采用常规治疗加休息;治疗组20例采用常规治疗加运动组,进行有氧运动训练12周,测定训练前后患者运动耐力和血浆ET-1、CGRP水平并分析其与心肌损伤的关系。结果老年CHF患者治疗前血浆ET-1、CGRP显著高于正常对照组（P〈0.05）;12周治疗后2组CHF患者血浆CK-MB、ET-1和CGRP降低（P〈0.05）,常规治疗加运动组降低更加显著具有统计学意义。结论老年心力衰竭患者ET-1、CGRP分泌失调,可能参与心肌损伤过程,有氧运动训练能降低血浆ET-1、CGRP水平减轻心肌损伤。

The effects of aerobic exercise therapy on plasma CGRP, ET-1 and myocardial injury in patients with chronic heart failure

Objective To investigate the changes of plasma CGRP and ET-1 after aerobic exercise in patients with chronic heart failure（CHF）,and relationship between myocardial injury and ET-1,CGRP.Methods Thirty-eight patients were enrolled and randomly divided into two groups： a training group and a rest group.The patients of both groups were both given conventional internal medicine therapy,and the patients of the training group were given aerobic exercise in addition.The exercise tolerance,the levels of plasma CGRP,ET-1 and CK-MB in patients of two groups were determined before and after 12 weeks of programmed aerobic exercise.Results The plasma CGRP and ET-1 levels of patients were higher than those of normal control people at rest,and positively correlated with CK-MB.After 12 weeks therapy,the plasma CGRP,ET-1 and CK-MB levels of patients were induced,and the levels of CGRP,ET-1,CK-MB in earobic exercise groups were significantly induced.Conclusion The plasma ET-1 and CGRP levels are abnormal in elderly CHF patients and may be correlated with myocardial injury.The earobic exercise can induce the plasmaCGRP,ET-1 levels of patients,and earobic exercise may ameliorate myocardial injury process.