Administration de courte durée de prednisolone et sécrétion d'érythropoïétine

Introduction

The aim of the study is to assess the effects of a short-term therapeutical prednisolone intake on erythropoietin (EPO) secretion.

Synthesis

We studied, according to a double-blind, randomized cross-over protocol, the effects of a 7 day prednisolone intake (60 mg/day) in 10 healthy male subjects on hematocrit, EPO and hemoglobin concentrations. No significant change was found between the treatments (prednisolone/placebo) in the parameters investigated.

Conclusion

In view of the results obtained, short-term therapeutic glucocorticoid intake did not induce any enhancement of erythropoiesis via EPO stimulation that can result in ergogenic advantage during submaximal exercise.