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Distribution of Fos-like immunoreactivity in the caudal medullary reticular formation following noxious facial stimulation in the rat |
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| Authors: | Yoko Mineta Elon Eisenberg Andrew M. Strassman |
| Affiliation: | (1) Anesthesiology Department, Saga Medical School, Saga, Japan;(2) Department of Neurology, Massachusetts General Hospital, Boston, MA, USA;(3) Department of Anesthesia, Beth Israel Hospital, Boston, MA, USA;(4) Department of Neurobiology, Harvard Medical School, 220 Longwood Ave, 02115 Boston, MA, USA |
| Abstract: | To investigate the topographic organization of nociceptive neurons in the caudal medullary reticular formation, the distribution of cells that exhibit c-fos expression was examined following a unilateral noxious facial stimulus: subcutaneous injection of formalin into the vibrissal pad of awake rats. Labelling for Fos-like immunoreactivity was present in a somatotopic distribution in a region of the lateral reticular formation adjacent to trigeminal nucleus caudalis, which corresponds approximately to lamina V of the medullary dorsal horn. Labelling in adjacent regions of the reticular formation showed no somatotopy but was predominantly ipsilateral. Contralateral labelling was concentrated ventrolaterally around the lateral reticular nucleus and dorsally near the nucleus of the solitary tract. |
| Keywords: | Medullary reticular formation c-fos Nociception Trigeminal nucleus caudalis Medullary dorsal horn |
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