血清血管生成素1水平与急性脑梗死发病、病情严重程度及90 d预后的关系

目的探讨血清血管生成素1(Ang-1)水平与急性脑梗死发病、病情严重程度及90 d预后的关系。方法对132例急性脑梗死患者(病例组)及108名健康体检者(对照组)进行血清Ang-1水平检测,同时采集相关的临床资料。病例组入院时进行NIHSS评分,将NIHSS评分5分者定义为病情轻度组,5~15分为病情中度组,≥16分为病情重度组。病例组90 d后随访行mRS评分,将mRS评分≤2分者定义为预后良好组,2分者定义为预后不良组。结果病例组吸烟史、高血压病、糖尿病、心房纤颤的比例明显高于对照组,血清Ang-1水平明显低于对照组(均P0.05)。Logistic回归分析显示,糖尿病及血清Ang-1水平均与急性脑梗死的发病密切相关(均P0.01)。病情轻度组患者血清Ang-1水平(1.12±0.35)ng/ml]与病情中度组(0.96±0.39)ng/ml]、病情重度组(0.76±0.49)ng/ml]比较,差异有统计学意义(P=0.003)。进一步分析显示,急性脑梗死患者病情严重程度与血清Ang-1水平呈负相关(r=-0.267,P=0.002)。预后不良组患者的入院时NIHSS评分、高血压病、糖尿病、心房纤颤的比例均明显高于预后良好组,而血清Ang-1水平明显低于预后良好组显著降低(均P0.05)。Logistic回归分析显示,入院时NIHSS评分及血清Ang-1水平均与急性脑梗死患者90 d预后密切相关(均P0.01)。结论急性脑梗死患者的血清Ang-1水平较低,且血清Ang-1水平与急性脑梗死的发病、病情严重程度及90 d预后均密切相关。

Relationship between serum Angiopoietin-1 level and the onset,the severity and the prognosis at 90 d of acute cerebral infarction

Objective To investigate the relationship between serum Angiopoietin-1 ( Ang-1 ) level and the onset, the severity and the prognosis at 90 d of acute cerebral infarction.Methods The level of serum Ang-1 was measured in 132 acute cerebral infarction patients ( case group ) and 108 healthy controls ( control group ) .The relevant clinical data was also collected.NIHSS was assessed at admission.The severity of the condition was defined according to the NIHSS score.NIHSS score <5, 5 -15 and ≥16 were defined as minor, moderate and severe condition, respectively.mRS was assessed at 90 d after admission.mRS≤2 was defined as good outcome and otherwise defined as poor outcome.Results Compared with control group, proportion of patients who had a history of smoking, hypertension, diabetes mellitus and atrial fibrillation were significant higher, serum Ang-1 concentration was significant lower ( all P<0.05 ) .Logistic analysis showed that serum Ang-1 level and a history of diabetes mellitus were associated with the occurrence of acute cerebral infarction ( all P<0.01 ) .The serum Ang-1 level in minor, moderate and severe condition patients was (1.12 ±0.35) ng/ml, (0.96 ±0.39) ng/ml and (0.76 ±0.49) ng/ml.There were significant differences among them ( P=0.003) .There was a significant relationship between the severity and the serum Ang-1 level ( r=-0.267, P=0.002 ) .Compared with good outcome patients, the poor outcome patients had significant higher NIHSS score and higher proportion of a history of hypertension, diabetes mellitus, atrial fibrillation, and lower serum Ang-1 concentration ( all P<0.05 ) .NIHSS score and serum Ang-1 concentration at admission had a significant relationship with 90 d outcome of acute cerebral infarction patients ( all P<0.01) .Conclusion Serum Ang-1 level was lower in acute cerebral infarction patients and it had significant relationship with the onset, severity and 90 d outcome of acute cerebral infaration.