帕金森病患者营养状况及其相关因素分析

目的研究帕金森病(PD)患者营养状况及其相关因素。方法收集180名PD患者为研究对象,应用量表系统性评估患者运动及非运动症状,采用微营养评定法(MNA-SF)评估营养状况。结果正常营养状态与非正常营养状态PD患者间病程、统一PD评分量表Ⅲ(UPDRSⅢ)、H-Y分期及非运动症状的差异均有统计学意义(P0.05~0.01)。二元Logistics回归结果显示H-Y分期(OR=2.35,95%CI:1.24~4.45,P=0.007)、抑郁情绪(OR=1.39,95%CI:1.25~1.67,P0.001)与非正常营养状态显著相关。结论 PD患者营养状况与其疾病本身、运动症状、非运动症状密切相关。

Analysis of nutritional status and related factors in patients with Parkinson's disease

Objective To explore the nutritional status and it's relative factors of patients with Parkinson's disease ( PD) .Methods One hundred and eighty PD patients were sellected in this study.All the motor and non-motor symptoms of PD patients were evaluated by PD scales, and mini Nutritional Assessment ( MNA )-SF questionnaires were used to evaluate their nutritional status.Results The differences of PD duration, Unified PD Rating Scale Ⅲ ( UPDRSⅢ) , H-Y stage and non-motor systems between normal nutritional status and abnormal nutritional status PD patients were statistically significant (P<0.05-0.01).The forward binary Logistic regression model indicated that H-Y stage (OR=2.35,95%CI:1.24-4.45,P=0.007) and depression (OR=1.39,95%CI:1.25-1.67,P<0.001) were closely associated with abnormal nutritional status.Conclusion The disease itself, motor systems and non-motor systems are closely associated with nutritional status in PD patients.