2型糖尿病患者皮肤交感反应异常情况及其相关因素

目的探讨2型糖尿病患者皮肤交感反应(SSR)异常情况及其相关因素。方法对354例2型糖尿病患者及65名健康体检者进行SSR检测。根据SSR参考值将2型糖尿病患者分为SSR正常组和SSR异常组,比较两组的临床资料。采用Logistic回归分析2型糖尿病患者SSR异常的相关因素。结果 SSR正常组为238例(67.23%),SSR异常组为116例(32.77%)。SSR异常组中上肢异常率(16.95%)显著低于下肢异常率(27.68%)(P=0.001)。与SSR正常组比较,SSR异常组病程显著延长,神经传导速度(NCV)异常及糖尿病视网膜病变比率显著增高(均P0.01),其余各指标差异均无统计学意义。Logistic回归分析显示,视网膜病变(OR=1.588,95%CI:0.991~2.545,P=0.045)及NCV异常(OR=3.052,95%CI:1.847~5.042,P=0.000)是2型糖尿病患者SSR异常的独立相关因素。结论糖尿病患者SSR的异常率为32.77%;下肢异常率明显高于上肢。糖尿病病程越长,越容易发生SSR异常。糖尿病视网膜病变和NCV异常是2型糖尿病患者SSR异常相关的独立相关因素。

The abnormality and its related factors of sympathetic skin response in patients with type 2 diabetes mellitus

Objective To investigate the abnormality and its related factors of sympathetic skin response ( SSR) in patients with type 2 diabetes mellitus.Methods SSR tests were performed in 354 patients with type 2 diabetes mellitus and 65 healthy cases.The type 2 diabetes mellitus patients were divided into normal SSR group and abnormal SSR group according to the SSR reference value.Clinical data were compared between the two groups. Logistic regression analysis was applied to analyze the related factors with abnormal SSR in patients with type 2 diabetes mellitus.Results There were 238 cases (67.23%) in SSR group and 116 cases(32.77%) in abnormal SSR group.In abnormal SSR group, the SSR abnormal rate in upper limbs (16.95%) was significantly lower than that in lower limbs (27.68%) (P=0.001).Compared with normal SSR group, the duration of diabetes were prolonged significantly, the incidence of diabetic retinopathy and nerve conduction velocity ( NCV ) abnormality in SSR abnormal group was significantly higher (all P<0.01), and there was no statistic significant difference in other factors between the two groups.Logistic regression analysis shows that diabetic retinopathy ( OR=1.588, 95%CI:0.991-2.545, P=0.045), and NCV abnormality (OR=3.052, 95%CI:1.847-5.042, P=0.000), were the independent related factors of SSR abnormality in patients with type 2 diabetes mellitus.Conclusions The abnormal rate of SSR in patients with type 2 diabetes mellitus is 32.77%.The abnormal rate in lower limbs is significantly higher than that in upper limbs.The longer duration of diabetes, the easier SSR abnormal to be occurred.Diabetic retinopathy and NCV abnormality are the independent related factors of SSR abnormality in patients with type 2 diabetes mellitus.