长期服用阿立哌唑与氯氮平对精神分裂症患者血清心肌酶的影响

目的：探讨长期服用阿立哌唑与氯氮平对精神分裂症患者血清心肌酶水平的影响。方法对84例服用阿立哌唑及85例服用氯氮平治疗时间＞3 a的精神分裂症患者进行血清心肌酶水平检测分析，指标包括肌酸激酶、肌酸激酶同工酶MB亚型、乳酸脱氢酶和天门冬氨酸氨基转移酶。结果两组肌酸激酶、肌酸激酶同工酶MB亚型、乳酸脱氢酶水平均高于正常值，但氯氮平组显著高于阿立哌唑组（ P＜0．05或0．01）；两组天门冬氨酸氨基转移酶水平与正常值比较均无明显变化。结论精神分裂症患者长期服用阿立哌唑与氯氮平治疗均可导致血清心肌酶水平不同程度的升高，氯氮平升高更为显著，应引起临床医师的关注。

Effects of long-term use of aripiprazole and clozapine on myo-cardial enzymes of patients with schizophrenia

Objective To explore the effects of long‐term use of aripiprazole and clozapine on myocardial enzymes of patients with schizophrenia .Methods Serum myocardial enzymes lev‐els were detected and analyzed in 84 schizophrenics on aripiprazole and 85 ones on clozapine > 3 years ,in‐dexes consisted of creatine kinase (CK) ,creatine kinase isoenzyme MB (CK‐MB) ,lactate dehydrogenase ( LDH) and aspertate aminotransferase (AST ) .Results The CK ,CK‐MB and LDH levels of both groups were all higher than normal value ,but those significantly higher in clizapine than in aripiprazole group (P<0 .05 or 0 .01);AST levels of both groups had no significant difference from normal value . Conclusion Long‐term use of aripiprazole or clozapine could induce the increases of serum myocardial en‐zymes levels in schizophrenics in different degrees ,especially clozapine ,as should be paid attention to .