立体定向丘脑腹中间核毁损术治疗书写痉挛的疗效评估 |
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引用本文: | 李建宇,张宇清,庄平,李勇杰.立体定向丘脑腹中间核毁损术治疗书写痉挛的疗效评估[J].临床神经外科杂志,2016(6):412-414. |
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作者姓名: | 李建宇 张宇清 庄平 李勇杰 |
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作者单位: | 10053 北京,首都医科大学宣武医院功能神经外科,北京市功能神经外科研究所 |
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基金项目: | 国家自然科学基金(81371256) |
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摘 要: | 目的探讨丘脑腹中间(Vim)核毁损术治疗书写痉挛的有效性和安全性。方法采用微电极引导下左侧丘脑Vim核毁损治疗书写痉挛(WC)患者47例,其中男32例,女15例;年龄15~64岁,平均(28.9±10.7)岁;病程2~21年。在术前和术后,采用书写痉挛评分量表(the writer's cramp rating scale,WCRS)对患者进行评分。结果全部患者毁损手术当时症状就明显改善,肘部、腕部和手指痉挛明显缓解,写字的流利程度和速度明显提升。其中2例患者(4.2%)出现一过性的右手指尖麻木;另有3例患者(6.4%)出现一过性言语不流利;上述并发症在3个月内完全恢复,没有永久性并发症发生。术后对患者进行电话随访,随访时间6~36个月,平均23个月;结果显示,患者的症状改善稳定;其中有3例患者失随访。另外,有1例患者因症状反复,再次行丘脑Vim核毁损术,术后症状改善明显。结论丘脑Vim核毁损术治疗书写痉挛是一种有效、安全的手术方式。
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关 键 词: | 书写痉挛 丘脑腹中间核 脑深部核团毁损术 |
Stereotactic selective thalamotomy for treatment of writer's cramp |
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Abstract: | Objective To explore the efficacy and safety of stereotactic selective thalamotomy for the treatment of writer's cramp( WC) .Methods 47 patients(32 men,15 women,age 15-64 years, mean 28.9 years) with medically intractable task-specific focal dystonia of the hand underwent Vim thalamotomy.The stereotactic target was chosen at ventralis intermedius nucleus. The mean duration of the symptom ranged from 2 to 21 years ( mean 5 .5 years ) .Results All patients showed immediate postoperative disappearance of dystonic symptoms , and the effect was sustained during the follow-up period ( 6-36 months, mean 23 months ) , except in 3 cases.One patient showed partial recurrence of the symptom and underwent second thalamotomy 6 months after the initial surgery with satisfactory results.The score on WC rating scale decreased significantly (P<0.001) after Vim thalamotomy.There were no permanent operative complications.There was no mortality or permanent morbidity.Conclusion Although a longer follow-up is needed, stereotactic Vim thalamotomy is a useful and safe therapeutic option for writer's cramp. |
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Keywords: | writer's cramp ventralis intermedius nucleus of thalamotomy |
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