度洛西汀治疗广泛性焦虑症对照研究

目的：评价度洛西汀治疗广泛性焦虑障碍患者的疗效和安全性。方法将60例广泛性焦虑障碍患者按随机数字表法分为两组，每组30例，研究组口服度洛西汀治疗，对照组口服阿普唑仑治疗，观察6周。于治疗前后采用汉密顿焦虑量表评定临床疗效，副反应量表评定不良反应。结果治疗1周末起两组汉密顿焦虑量表评分均较治疗前显著下降（P＜0．05），并随着治疗时间的延续均呈持续性下降，同期两组间评分比较无显著性差异（P＞0．05）；治疗6周末研究组总有效率为86．7％，对照组为83．3％，两组比较差异无显著性（ P＞0．05）。两组不良反应较轻微，研究组发生率为23．3％，对照组为36．7％，两组比较差异无显著性（ P＞0．05）。结论度洛西汀治疗广泛性焦虑障碍疗效显著，不良反应较轻微，安全性高。

A control study of duloxetine in the treatment of generalized anxiety disorder

Objective To evaluate the efficacy and safety of duloxetine in the treatment of patient with generalized anxiety disorder (GAD) .Methods Sixty GADS patients randomly assigned to two groups of 30 ones each ,research group took orally duloxetine and control group did alprazolam for 6 weeks .Effica‐cies were assessed with the Hamiltom Anxiety Scale (HAMA) before and after treatment and adverse reac‐tions with the Treatment Emergent Symptom Scale (TESS) .Results Since the end of the 1st week the HAMA scores of both groups lowered more significantly compared with pretreatment (P<0 .05) ,did con‐tinuously as treatment time went on ,and had no significant group difference (P>0 .05);at the end of the 6th week the total effective rate was respectively 86 .67 % in research and 83 .33% in control group ,which showed no significant group difference (P>0 .05) .Adverse reactions of both groups were mild and their incidences had no significant group difference (research :23 .3% vs .control group :36 .7% , P>0 .05) . Conclusion Duloxetine has an evident effect ,mild adverse reactions and higher safety in the treatment of generalized anxiety disorder .