Halothane enhances the binding of diazepam to synaptic membranes from rat cerebral cortex |
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Authors: | S Nakao T Arai M Murakawa K Mori |
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Institution: | Department of Anesthesia, Kyoto University Hospital, Japan. |
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Abstract: | The effects of halothane on diazepam binding to the rat cerebral synaptic membranes were investigated. Halothane at the concentrations of 0.63, 1.3 and 4.1 mmol/l increased the binding by 12, 23 and 33%, respectively, compared to the control in the absence of halothane. The increments were dependent on the presence of Cl-. The findings indicate that halothane and diazepam have an interaction at receptor level. |
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Keywords: | Diazepam GABA receptor complex halothane MAC synaptic membrane |
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