Effects of Pycnogenol on cisplatin-induced optic nerve injury: an experimental study |
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| Authors: | Erel Icel Burcu Agcayazi Yücel Karakurt Hayati Yilmaz Ferda Keskin Çimen |
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| Affiliation: | 1. Department of Ophthalmology, Erzincan University Hospital, College of Medicine, Erzincan, Turkey;2. Department of Pathology, Erzincan University Hospital, College of Medicine, Erzincan, Turkey |
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| Abstract: | Aim: To determine the effects of Pycnogenol on cisplatin-induced optic nerve damage.Material and method: Totally 18 albino Wistar male rats were assigned into three groups, with six rats in each group as follows: healthy controls (HC group), only cisplatin (2.5?mg/kg) administered group (CIS group) and Pycnogenol (40?mg/kg)?+?cisplatin (2.5?mg/kg) administered group (PYC group). We analyzed the levels of malondialdehyde (MDA) as a marker of lipid peroxidation and oxidative stress, total glutathione (tGSH) as a marker of antioxidant status, nuclear factor-kappa B (NF-κB) and tumor necrosis factor alpha (TNF-α) as inflammatory markers, total oxidative status (TOS) and total antioxidant status (TAS) on eye tissue together with histopathological evaluation of optic nerve in an experimental model.Results: In CIS group MDA, TOS, TNF-α and NF-κB levels were statistically significantly higher (p?p?p?p?Conclusion: Pycnogenol pretreatment was highly effective in preventing augmentation of cisplatin-induced oxidative stress and inflammation in eye tissue. |
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| Keywords: | Pycnogenol cisplatin optic nerve damage malondialdehyde oxidative stress |
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