Usefulness of repetitive transcranial magnetic stimulation as a maintenance treatment in patients with major depression |
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Authors: | Frédéric Haesebaert Rémi Moirand Anne-Marie Schott-Pethelaz Emmanuel Poulet |
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Affiliation: | 1. INSERM U1028, CNRS UMR5292, Lyon Neuroscience Research Center, ΨR2 Team, University Lyon, France;2. Centre Hospitalier Le Vinatier, Bron, France;3. P?le “Information Médicale Evaluation Recherche” (IMER), Lyon, France;4. Service de Psychiatrie des urgences, CHU Lyon, H?pital Edouard Herriot, Lyon, France |
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Abstract: | Objectives: To investigate the clinical efficacy of repetitive transcranial magnetic stimulation (rTMS), venlafaxine or a combination of both treatments as a maintenance treatment in patients with treatment-resistant depression (TRD).Methods: In a three-arm open-label study, 66 patients, including 45 remitters, who responded to rTMS (n?=?25), venlafaxine (n?=?22), or a combination of both treatments (n?=?19) continued to receive the treatment that led to a response as a maintenance treatment over 12 months. Maintenance rTMS was administered twice per week for 1 month, once per week for 2 months, and once every 2 weeks for 9 months. Venlafaxine was maintained at the dose that induced a clinical response (150 or 225?mg/day).Results: After the 12-month follow-up, the rates of remitters (HDRS?8) were not different between the three groups (χ2?=?1.25; P?=?.3). The rates of patients who not relapsed (HDRS?15) were not different between groups (χ2?=?0.33; P?=?.8): 40.0% in the rTMS group, 45.1% in the venlafaxine group and 36.9% in the combination group.Conclusions: The three maintenance approaches exhibited similar efficacies in relapse prevention and the maintenance of remission in patients with TRD. |
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Keywords: | Depression DLPFC rTMS transcranial magnetic stimulation maintenance treatment |
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