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Hepatoprotective effect of tempol on oxidative toxic stress in STZ-induced diabetic rats |
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| Authors: | Rozhin Ghadermazi Farhad Khoshjou Seyed Mostafa Hossini Zijoud Hamid Behrooj Nejat Kheiripour Maziar Ganji |
| Affiliation: | 1. Student Research Center,;2. Urology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran,;3. Nephrology &4. Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran,;5. Department of Biochemistry, Faculty of Medicine, and |
| Abstract: | Tempol is a synthetic antioxidant. Since many studies revealed the protective effect of antioxidants on liver, current study was performed to assess the hepatoprotective effects of tempol on streptozotocin induced diabetic rats. Blood glucose, oxidative toxic stress (OTS) biomarkers and liver enzymes were measured. Findings showed that tempol significantly decreased serum levels of glucose in tempol treated group. Also treatment with tempol significantly reduced AST and ALT compared to diabetic control group (p? |
| Keywords: | Tempol ALT AST oxidative toxic stress diabetes |