螺旋藻多糖对糖尿病小鼠抗氧化能力的影响

腹腔注射四氧嘧啶（ＡＬＸ）２００mg/kg建立糖尿病模型小鼠，并随机分为４组，分别用螺旋藻多糖（ＰＳＰ）１００mg/kg、２００mg/kg及阳性对照药优降糖２mg/kg灌胃给药，糖尿病模型对照组则给等容积生理盐水，连续１４d后，分别测定各组小鼠血糖、血清ＳＯＤ活性、ＭＤＡ含量及全血ＧＳＨ－Ｐx活性与ＧＳＨ含量。结果与糖尿病模型对照组相比，ＰＳＰ能使ＡＬＸ所致糖尿病小鼠血糖降低（Ｐ＜０.０１）；血清ＳＯＤ活性、全血ＧＳＨ－Ｐx活性及ＧＳＨ一显著回升（Ｐ＜０.０１）；血清ＭＤＡ含量明显下降（Ｐ＜０.０１）。结果表明ＰＳＰ能降低ＡＬＸ性糖尿病小鼠高血糖并显著增强其抗氧化能力。提示ＰＳＰ降血糖作用的机制可能与其增强糖尿病鼠抗氧化能力有关。

Effect of Polysaccharide from Spirulina Platensis on Anti-Oxidation in Experimental Diabetic Mice

The diabetic model mice were established by intraperitonealinjection of alloxan(ALX) 200 mg/kg. Then the mice were randomly divided into four groups. Among them, two groups were given spirulina platensis polysach aride(PSP) 100mg/kg, 200 mg/kg respectively by ig administration, and one group was received Glibenclamide 2 mg/kg by ig adminstration as the positive control, another group was given normal saline as the diabetic model control. After 14 days anim als were killed to determine blood sugar, SOD, MDA, GSH-Px etc. It was found that PSP could obviously decrease the blood sugar, and significantly enhance the ac tivities of serum SOD and blood GSH-Px in diabetic mice induced by ALX. In addi t ion, the results also showed that PSP could remarkably decrease the content of serum MDA and greatly increase the concentration of blood GSH in the mice. It is suggested that PSP could decrease the level of blood sugar and effectively enhance the ability of anti-oxidation in the diabetic mice induced by ALX.