| 动态浊度法定量检测右旋糖酐40氯化钠注射液中细菌内毒素 |
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| 引用本文： | 王晓晶,王梅娟.动态浊度法定量检测右旋糖酐40氯化钠注射液中细菌内毒素[J].药学与临床研究,2003,11(3):60-61. |
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| 作者姓名： | 王晓晶 王梅娟 |
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| 作者单位： | 盐城市药品检验所盐城224002 |
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| 摘 要： | 目的 建立定量检测右旋糖酐40氯化钠注射液中细菌内毒素试验方法。方法 采用《中国药典》2000年版(二部)附录检测细菌内毒素的动态浊度法。结果 右旋糖酐40氯化钠注射液用细菌内毒素定量法，检测无干扰因素影响，内毒素回收率在50％—200％范围内。结论 使用动态浊度法定量检测右旋糖酐40氯化钠注射液的细菌内毒素是可行的，可用细菌内毒素定量法代替家兔热原检查法。
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| 关 键 词： | 动态浊度法 定量检测 右旋糖酐40氯化钠注射液 中细菌内毒素 |
| 收稿时间： | 2002/12/23 0:00:00 |
Application of the Turbidimetric-kinetic Method for the Measurement of Endotoxin in Dextran 40 Sodium Chloride Injection |
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| Wang Xiaojing and Wang Meijuan.Application of the Turbidimetric-kinetic Method for the Measurement of Endotoxin in Dextran 40 Sodium Chloride Injection[J].Pharmacertical and Clinical Research,2003,11(3):60-61. |
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| Authors: | Wang Xiaojing and Wang Meijuan |
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| Abstract: | Objective To develop an assay for determination of bacterial endotoxin(BET) in dextran 40 sodium chloride injection.Methods BET was determinated by turbidimetric-kinetic method.Results The content in dextran 40 sodium chloride injection did not interfere with the quantitation of BET .The Recovery of BET was between 50% and 200%. Conclusion The methed is proved to be suitable for determination of the BET in dextran 40 sodium chloride injection and could be used as an alternative for the rabbit pyrogen test to the injection. |
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| Keywords: | Dextran 40 sodium chloride injection Bacterial endotoxin Turbidimetric-kinetic method Interfere factors test |
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