| EFFECTS OF ET-1 ON MITOGENESIS AND COLLAGEN SYNTHESIS IN CULTURED CARDIAC FIBROBLASTS |
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| 作者姓名： | 王长谦 黄定九 陈润芬 谢秀兰 丁弘毅 徐依敏 |
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| 作者单位： | Department of Cardiotogy Renji Hospital，SSMU Shanghai 200001 |
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| 摘 要： | R6sum.0bjectiIExaminerlesefletSdeET-1suriamitOgdn,seetiaSynthdseducollagdnedanslesfibroblastescardiaquesenculture.Mfth0desLamitogdneseetlaSynthdseducollagdnedansleslibroblastescardiaquesenculturesontreSPectivementme8urdesparl'incorPorationdeW-TdRetde'H-proline.RJsuItasET-1enconcentration1O-"~1O-'mol/Laugmenteletauxd'incorPorationde3H-TdRetde'H-prolinedansleslibrobla8tescardiaque8enculturedelaCondose~ddPendante.Co"cI"sioDET-1peutstimulerlamitogdndsedesfibroblastescardiaquesencultu…
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EFFECTS OF ET-1 ON MITOGENESIS AND COLLAGEN SYNTHESIS IN CULTURED CARDIAC FIBROBLASTS |
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| Wang Changqian, Huang Ding jiu, Chen Run fen,Xie Xiulan, Ding Hngyi, Xu Yimin.EFFECTS OF ET-1 ON MITOGENESIS AND COLLAGEN SYNTHESIS IN CULTURED CARDIAC FIBROBLASTS[J].Journal of Shanghai Second Medical University(Foreign Language Edition),1999(2). |
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| Authors: | Wang Changqian Huang Ding jiu Chen Run fen Xie Xiulan Ding Hngyi Xu Yimin |
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| Institution: | Wang Changqian, Huang Ding jiu, Chen Run fen,Xie Xiulan, Ding H0ngyi, Xu Yimin |
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| Abstract: | Objective To examine the eflects of endothelin - 1 (ET- 1) on mitogenesis and collagen synthesis in cultured cardiac libroblasts. Methods The mitogenesis and collagen synthesis in cultured cardiac fibroblasts were assessed by incorporation of 3H- TdR and 3H-proline respectively. Results 10-12~10-8mol/L ET- 1 could enhance the incorporation rate of 3H- TdR and 3H-proline in an dose - dependent manner in cultured cardiac libroblasts. Conclusion ET- 1 could stimulate the mitogenesis of cultured cardiac fibroblasts and could enhance collagen synthesis by cultured cardiac libroblasts, this effect of ET- 1 is probably related to the formation of myocardial collagen network remodeling. |
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| Keywords: | ventricular remodeling myocardial collagen network endothelin-1 |
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