脑梗死运动障碍患者早期康复治疗与氧化应激的关系

目的研究脑梗死早期运动障碍患者经过康复治疗后,体内氧化应激水平的改变并探讨其机制。方法回顾性对比分析2010年3月至2012年12月本院神经内科住院的脑梗死早期康复治疗患者与未做康复治疗患者各45例临床资料,采用临床神经功能缺损程度评分标准评定脑患者的病情严重程度,检测入院时及治疗后血中ROS、SOD水平,对日常生活活动能力(Barthel指数)及运动功能(FMA)进行评定,并做出统计学分析。结果治疗前两组患者间FMA评分、Barthel指数、血清中ROS及SOD水平比较差异均无统计学意义(P0.05),经过不同治疗3周后,两组患者间FMA评分、Barthel指数、血清中ROS及SOD水平较治疗前均有统计学意义(P0.05)。结论脑梗死后康复锻炼可降低体内氧化应激,减轻其对机体的损害作用。

Relationship between oxidative stress and treatment rehabilitation in early cerebral infarction

Objective To observe the protective effect and investigate the mechanism of early cerebral infarction patients with dyskinesia after rehabilitation treatment. Methods The clinical data of cerebral infarction patients who were with early rehabilitating （45 cases ） and without rehabilitating （45 cases） at the Department of Neurology from March 2010 to December 2012 were respectively analyzed. The ROS, SOD levels in serum, the ADL and FMA scale were detected, and statistical analysis was made. Results Before treatment, the two groups had no statistically significant difference between patients in FMA score, Barthel index, serum ROS and SOD levels （P 〉 0.05 ）, but after 3 weeks of different treatment, these results had remarkably changed （ P 〈 0.05 ）. Conclusion The exercise in early cerebral infarction may reduce the excessive oxidative stress and we should pay attention to the importance of it.