慢性阻塞性肺疾病患者呼出气一氧化氮测定的临床意义

目的观察慢性阻塞性肺疾病(COPD)患者呼出气一氧化氮(FENO)的变化及其临床意义。方法分别测定25例健康对照组、25例COPD急性发作期(AECOPD)患者治疗前、后的FENO值,AECOPD组患者治疗前后分别测定肺功能(FEV1绝对值、FEV1%预计值)。结果①AECOPD组治疗前FENO值明显高于健康对照组(24.4±5.11 vs 16.97±3.78,P0.01),治疗后与治疗前比较FENO值明显下降(18.3±2.76 vs 24.4±5.11,P0.01),但治疗后FENO值与健康对照组差异无统计学意义(18.3±2.76 vs 16.97±3.78,P=0.245);②AECOPD患者治疗前后FENO值与肺功能FEV1、FEV1%高低均无明显相关性(P0.05)。结论 AECOPD时NO生成及释放增多,测定FENO的升高可提示存在气道炎症,可用于预测患者抗炎治疗的效果。

Clinical significance of measuring fractional exhaled nitric oxide in patients with chronic obstructive pulmonary disease

Objective To evaluate the clinical significance of fractional exhaled nitric oxide （FENO） in patients with chronic obstructive pulmonary disease （COPD）. Methods FENO values in 25 cases of healthy control group, 25 cases of acute exacerbation of COPD （AECOPD） group before and after the treatment were measured respectively. The FEV1, FEV1% pred were measured before and after AECOPD treatment. Results ①FENO values in AECOPD patients before treatment were significantly higher than those in healthy control group （24.4 ± 5.11 vs 16.97 ± 3.78, P 〈 0.01, and decreased significantly after treatment （24.4 ± 5.11 vs 18.3 ± 2.76, P 〈 0.01 ）. However, there was no significant difference between healthy controls and AECOPD patients after treatment （ 16.97 ± 3.78 vs 18.3 ± 2.76, P = 0. 245）. ②FENO values in AECOPD patients were not significantly correlated with FEV1, FEV1% level of lung function before and after treatment （ P 〉 0.05 ）. Conclusion FENO can be considered as a marker of airway infla ammation, and used in forecasting the effect of anti -inflammatory therapy in patients.