|
|||||
|
|
| GSTP1和RASSF1A基因多态性和环境因素与前列腺癌的相关性分析 | |
| 引用本文： | 徐兴兴,常文军,侯建国,徐丹枫,崔心刚,翟羽佳,王国萍,张宏伟,曹广文.GSTP1和RASSF1A基因多态性和环境因素与前列腺癌的相关性分析[J].第二军医大学学报,2010,31(1):12-17. |
| 作者姓名： | 徐兴兴 常文军 侯建国 徐丹枫 崔心刚 翟羽佳 王国萍 张宏伟 曹广文 |
| 作者单位： | 1. 第二军医大学基础部流行病学教研室,上海,200433 2. 第二军医大学长海医院泌尿外科,上海,200433 3. 第二军医大学长征医院泌尿外科,上海,200003 4. 第二军医大学基础部流行病学教研室,上海,200433;海军航空工程学院青岛分院,青岛,266041 |
| 基金项目： | 国家自然科学基金(30671793)~~ |
| 摘 要： | 目的探讨GSTP1和RASSF1A基因多态性及环境因素和前列腺癌易感性之间的关系。方法采用TaqMan/MGB探针基因分型方法对103例前列腺癌患者和103例正常对照的中国汉族人群基因组DNA进行GSTP1和RASSF1A基因多态性检测,并结合环境因素应用多因素Logistic回归分析吸烟、饮酒、饮茶、猪肉和牛肉每周实际摄入量及各位点基因型与前列腺癌易感性之间的关系。结果GSTP1基因型AA、AG、GG在前列腺癌和对照人群中的比例分别为66.02%、22.33%、11.65%和67.96%、29.13%、2.91%,有统计学差异(χ2=6.35,P=0.04);RASSF1A基因型CC、CA、AA在前列腺癌和对照人群中的比例分别为88.34%,5.83%,5.83%和85.44%,12.62%,1.94%,无统计学差异(χ2=4.63,P=0.10)。多因素Logistic回归分析显示,饮茶者患前列腺癌的危险性是不饮茶者的0.40倍(95%CI,0.19～0.82),吸烟者患前列腺癌的危险性是不吸烟者的3.02倍(95%CI,1.44～6.32)。结论GSTP1和RASSF1A的基因多态性和中国汉族人群前列腺... |
| 关 键 词： | 前列腺肿瘤 病例对照研究 GSTP1 RASSF1A 遗传多态现象 |
| 收稿时间： | 2009/8/15 0:00:00 |
| 修稿时间： | 2009/12/11 0:00:00 |
Relationship of GSTP1,RASSF1A polymorphisms and environmental agent with susceptibility to prostate cancer:a case-control study |
|
| XU Xing-xing,CHANG Wen-jun,HOU Jian-guo,XU Dan-feng,CUI Xin-gang,ZHAI Yu-ji,WANG Guo-ping,ZHANG Hong-wei,CAO Guang-wen.Relationship of GSTP1,RASSF1A polymorphisms and environmental agent with susceptibility to prostate cancer:a case-control study[J].Academic Journal of Second Military Medical University,2010,31(1):12-17. | |
| Authors: | XU Xing-xing CHANG Wen-jun HOU Jian-guo XU Dan-feng CUI Xin-gang ZHAI Yu-ji WANG Guo-ping ZHANG Hong-wei CAO Guang-wen |
| Institution: | XU Xing-xing1,CHANG Wen-jun1,HOU Jian-guo2,XU Dan-feng3,CUI Xin-gang3,ZHAI Yu-jia1,4,WANG Guo-ping1,ZHANG Hong-wei1,CAO Guang-wen1 1. Department of Epidemiology,College Basic Medical Sciences,Second Military Medical University,Shanghai 200433,China 2. Department of Urology,Changhai Hospital,China 3. Department of Urology,Changzheng Hospital,Shanghai 200003,China 4. Qingdao Branch of Naval Aeronautical Engineering Academy,... |
| Abstract: | Objective To investigate relationship of GSTP1,RASSF1A polymorphisms and environmental agent with susceptibility to prostate cancer ( Pca). Methods The GSTP1 and RASSF1A genotypes were determined by TaqMan/MGB Probe Technology in 103 patients with Pca and 103 normal controls. Multivariate logistic regression model was used to assess the association of smoking,alcohol drinking,tea drinking,weekly pork and beef consumption,and the genetic polymorphisms with the susceptibility to Pca,while taking into consider... |
| Keywords: | prostatic neoplasms case-control studies GSTP1 RASSF1A genetic polymorphism |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |
| 点击此处可从《第二军医大学学报》浏览原始摘要信息 | |
| 点击此处可从《第二军医大学学报》下载免费的PDF全文 | |