HEMATOGENOUS DEVELOPMENT OF RAT MATURE GRANULOCYTIC LEUKEMIA

The oral administration of N, N'-2, 7-fluorenylenebisacetamide (2, 7-FAA) induces leukemia, especially mature granulocytic leukemia, in rats. We compared the distribution of nodular foci of 2,7-FAA-induced mature granulocytic leukemia with that of transplanted leukemia for the purpose of proving hematogenous development of leukemia. The bone marrow of the vertebral bodies was examined in the cases of scattered lesion of 2,7-FAA-induced and transplanted leukemia. The leukemic nodular foci were most frequently located around the center of the craniocaudal axis of the vertebral bodies in both leukemias. On the other hand, they were evenly distributed along the dorso-ventral axis in both leukemias. The similarity of the distribution of nodular foci between 2,7-FAA-induced and transplanted leukemia may be an evidence for the hypothesis that the former is spread by hematogenous metastasis.