Radioimmunoassay for detection of VP1 specific neutralizing antibodies of foot and mouth disease virus |
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| Authors: | E J Patzer M L Jackson D M Moore |
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| Institution: | 1. Genentech, Inc., 460 Point San Bruno Boulevard, South San Francisco, CA 94080 U.S.A.;2. U.S. Department of Agriculture, Plum Island Animal Disease Center, P.O. Box 848, Greenport, NY 11944, U.S.A. |
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| Abstract: | A solid-phase radioimmunoassay was developed for the detection of antibodies against a specific region of the VP1 protein of the A24 and 01 serotypes of foot and mouth disease virus. The antibody titers from the radioimmunoassay showed a positive correlation with neutralizing antibody titers determined by a mouse protection assay. The specificity of the assay resides in the peptide used as antigen. The assay is rapid, reproducible and does not require the use of whole virions. |
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| Keywords: | RIA FMD neutralizing antibodies |
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