| 上感颗粒对病毒性上呼吸道感染小鼠肺组织TLR3及PKR mRNA表达的影响 |
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| 引用本文： | 郑艳,耿连艺,盛夏,高峰,奚肇庆. 上感颗粒对病毒性上呼吸道感染小鼠肺组织TLR3及PKR mRNA表达的影响[J]. 南京医科大学学报(自然科学版), 2011, 0(3): 410-413 |
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| 作者姓名： | 郑艳 耿连艺 盛夏 高峰 奚肇庆 |
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| 作者单位： | 南京中医药大学第一临床医学院内科学教研室;东南大学医学院分子生物学实验室;江苏省中医院急诊科; |
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| 基金项目： | 2010南京中医药大学大学生实践创新训练计划; 2009江苏省教育厅研究生科研创新计划(CX09B-277Z); 国家中医药管理局08行业科研专项(200807041) |
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| 摘 要： | 目的:通过观察上感颗粒对病毒性上呼吸道感染小鼠肺组织TLR3及PKR mRNA表达的影响,来探讨其治疗病毒性上呼吸道感染可能的免疫调节机制。方法:ICR小鼠随机分为7组:正常对照组、模型组、抗病毒口服液组、利巴韦林组、上感颗粒大、中、低剂量组。病毒滴鼻后给药,观察其肺组织TLR3及PKR mRNA的表达。结果:抗病毒口服液、利巴韦林、上感颗粒可降低小鼠肺组织TLR3及PKR mRNA的表达,与模型组比较具有显著性差异(P<0.05)。结论:上感颗粒可抑制病毒性上呼吸道感染小鼠肺组织中TLR3及PKR mRNA的表达,可能为其免疫调节作用的机制之一。
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| 关 键 词： | 上感颗粒 病毒性上呼吸道感染 TLR3 PKR mRNA |
| 收稿时间： | 2010-07-30 |
Effect of Shanggan Granule on the express of TLR3 and PKR mRNA in lung of mice with viral upper respiratory tract infection |
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| ZHENG Yan,GENG Lian-yi,SHENG Xi,GAO Feng and XI Zhao-qing. Effect of Shanggan Granule on the express of TLR3 and PKR mRNA in lung of mice with viral upper respiratory tract infection[J]. Acta Universitatis Medicinalis Nanjing, 2011, 0(3): 410-413 |
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| Authors: | ZHENG Yan GENG Lian-yi SHENG Xi GAO Feng XI Zhao-qing |
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| Affiliation: | ZHENG Yan,GENG Lian-yi,SHENG Xia,GAO Feng1,XI Zhao-qing2*(Department of Internal Medicine,the First Clinical Medical Conllege,Nanjing University of TCM,Nanjing 210046,Lab of Molecular Biology,1School of Medicine,Southeast Univercity,Nanjing 210009,2Department of Emergency,Jiangsu Hospital of TCM,Nanjing 210029,China) |
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| Abstract: | Objective:To observe the effects of Shanggan Granule on the express of Toll-like receptor 3(TLR3) and double-stranded RNA-dependent protein kinase(PKR) mRNA in lung of mice with viral upper respiratory tract infection,and explore its immune regulation mechanism.Methods:ICR mice were randomly divided into normal group,model group,antiviral oral liquid group,ribavirin group,Shanggan Granule high-dose group,Shanggan Granule medium-dose group and Shanggan Granule low-dose group.Mice were infected with influenza... |
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| Keywords: | Shanggan Granule viral upper respiratory tract infection TLR3 PKR mRNA |
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