Calorie restriction (CR) reduces age-dependent decline of non-homologous end joining (NHEJ) activity in rat tissues |
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| Authors: | Lee Jae-Eun Heo Jee-In Park Seong-Hoon Kim Jeong-Hyeon Kho Yoon-Jung Kang Hong-Jun Chung Hae Young Yoon Jong-Lull Lee Jae-Yong |
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| Affiliation: | aDepartment of Family Medicine, Hangang Secred Heart Hospital, Hallym University Medical Center, Seoul, South Korea;bDepartment of Biochemistry, College of Medicine, Hallym University, Chuncheon, Gangwon-do, South Korea;cInstitute of Natural Medicine, College of Medicine, Hallym University, Chuncheon, Gangwon-do 200-702, South Korea;dDepartment of Radiation Oncology, Department of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA;eDepartment of Biochemistry, College of Pharmacy, Pusan University, Pusan, South Korea;fGDDB, Genetic Disease Research Section, NIDDK, National Institutes of Health, Building 10, Room 9D11, Bethesda, MD 20892, USA |
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| Abstract: | Even though CR has shown to enhance base excision repair (BER) and nucleotide excision repair (NER) capacities, it has not been reported whether CR can enhance non-homologous end joining (NHEJ) activity. To examine the effect of CR on NHEJ activity, ad libitum (AL)- and calorie restricted (CR)-dieted rats were used. Age-dependent decline of NHEJ activity was apparent in the lung, liver, and kidney and appeared to be slightly decreased in spleen. CR reduced age-dependent decline of NHEJ activity in all tissues, even though the extent of recovery was variable among tissues. Moreover, CR appeared to reduce age-dependent decline of XRCC4 protein level. These results suggest that CR could reduce age-dependent decline of NHEJ activity in various tissues of rats possibly through up-regulation of XRCC4. |
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| Keywords: | Calorie restriction NHEJ Aging XRCC4 |
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