| 布地奈德对哮喘气道重塑小鼠p-VEGFR2表达的影响及其机制研究 |
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| 引用本文： | 李涛,黄茂,刘红,刘媛.布地奈德对哮喘气道重塑小鼠p-VEGFR2表达的影响及其机制研究[J].南京医科大学学报,2011(3):308-313. |
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| 作者姓名： | 李涛 黄茂 刘红 刘媛 |
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| 作者单位： | 南京医科大学第一附属医院呼吸科; |
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| 基金项目： | 江苏省卫生厅“科教兴卫工程”-呼吸病学学科(实验室)开放课题资助 |
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| 摘 要： | 目的:磷酸化研究血管内皮生长因子受体2(VEGFR2)在哮喘气道重塑小鼠肺组织中的表达水平以及布地奈德对其干预作用.方法:24只BALB/c小鼠随机分为正常组、哮喘组以及布地奈德干预组,每组8只;以鸡卵清蛋白(OVA)致敏、激发建立慢性哮喘气道重塑模型.布地奈德干预组OVA激发前30 min给予布地奈德混悬液10 ml...
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| 关 键 词： | 支气管哮喘 气道重塑 血管内皮生长因子 磷酸化血管内皮生长因子受体2 布地奈德 |
| 收稿时间： | 2010/9/20 0:00:00 |
Effects of budesonide on the expression of phosphorylated VEGFR2 in asthmatic mice with airway remodeling |
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| LI Tao,HUANG Mao,LIU Hong and LIU Yuan.Effects of budesonide on the expression of phosphorylated VEGFR2 in asthmatic mice with airway remodeling[J].Acta Universitatis Medicinalis Nanjing,2011(3):308-313. |
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| Authors: | LI Tao HUANG Mao LIU Hong and LIU Yuan |
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| Institution: | LI Tao,HUANG Mao*,LIU Hong,LIU Yuan(Department of Respiration Medicine,the First Affiliated Hospital of NJMU,Nanjing 210029,China) |
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| Abstract: | Objective:To investigate effects of budesonide on the expression of phosphorylated vascular endothelial growth factor receptor 2(VEGFR2) in asthmatic mice with airway remodeling.Methods:Twenty-four BALB/c mice were randomly divided into control group,asthma group and budesonide intervention group.The mice were sensitized and challenged with ovalbumin(OVA) to establish the chronic asthmatic model.Budesonide(10 ml) was atomized half an hour before sensitization in budesonide intervention group.After finished ... |
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| Keywords: | bronchial asthma airway remodeling VEGF p-VEGFR2 budesonide |
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