| il23r基因多态与食管癌遗传易感性的关联研究 |
| |
| 引用本文： | 肖 勇,陈 维,曹维克,褚红军,郭 伟,潘善东,姜 洁,董 静,胡志斌,沈洪兵. il23r基因多态与食管癌遗传易感性的关联研究[J]. 南京医科大学学报(自然科学版), 2011, 0(4): 513-516 |
| |
| 作者姓名： | 肖 勇 陈 维 曹维克 褚红军 郭 伟 潘善东 姜 洁 董 静 胡志斌 沈洪兵 |
| |
| 作者单位： | 南京医科大学附属淮安第一医院心胸外科;南京医科大学公共卫生学院流行病与卫生统计学系;南京医科大学附属淮安第一医院中心实验室检验科; |
| |
| 基金项目： | 国家高技术研究发展计划(863)(2009AA022706); 南京医科大学肿瘤中心开放课题资助 |
| |
| 摘 要： | 目的:探讨白细胞介素23受体(IL23R)基因多态与中国人群食管癌易感性的关系。方法:采用病例-对照研究设计,收集经病理组织学确诊的食管癌新发病例共1 045例,性别、年龄等人口学特征与病例频数匹配的健康对照1047例。选取IL23R基因启动子区域SNP rs6682925 T>C以及第二外显子区域SNP rs1884444 T>G为研究位点。应用TaqMan基因分型技术进行基因型检测并进行相关统计分析,比较不同基因型与食管癌发病风险的关系。结果:在调整年龄、性别、吸烟、饮酒因素后,携带IL23R rs1884444 TG/GG基因型的个体发生食管癌的风险较携带IL23R rs1884444TT基因型者增加了20%(校正OR=1.20,95%CI=1.01～1.43),携带rs6682925 TC/CC基因型者发生食管癌的风险较携带TT基因型者增加17%(校正OR=1.17,95%CI=0.98～1.40)。分层分析结果显示rs1884444风险等位基因G和rs6682925风险等位基因C的危险作用在年轻者(≤60岁)和不饮酒者中尤为明显。结论:IL23R rs1884444和rs6682925多态与中国汉族...
|
| 关 键 词： | IL23R 单核苷酸多态性 食管癌 遗传易感性 |
| 收稿时间： | 2010-09-27 |
polymorphisms in il23r gene are associated with risk of esophageal cancer in chinese population |
| |
| xiao yong,chen wei,cao wei-ke,chu hong-jun,guo wei,pan shan-dong,jiang jie,dong jing,hu zhi-bin and shen hong-bing. polymorphisms in il23r gene are associated with risk of esophageal cancer in chinese population[J]. Acta Universitatis Medicinalis Nanjing, 2011, 0(4): 513-516 |
| |
| Authors: | xiao yong chen wei cao wei-ke chu hong-jun guo wei pan shan-dong jiang jie dong jing hu zhi-bin shen hong-bing |
| |
| Affiliation: | XIAO Yong,CHEN Wei1,CAO Wei-ke2,CHU Hong-jun,GUO Wei*,PAN Shan-dong1,JIANG Jie1,DONG Jing1,HU Zhi-bin1,3*,SHEN Hong-bing1,3(Department of Thoracic Surgery,the Affilated huai'an First Hospital of NJMU,Huaian 223300,1Department of Epidemiology and Biostatistics,School of Public Health,NJMU,Nanjing 210029,2Department of Laboratory Diagnosis,the Affilated Huai'an First Hospital of NJMU,3Jiangsu Key Laboratory of Cancer Biomarkers,Prevention and Treatment,Cancer Center,China) |
| |
| Abstract: | Objective:To investigate the associations between potentially functional polymorphisms of interleukin 23 receptor(IL23R) and esophageal cancer risk.Methods:A case-control study with 1 045 esophageal cancer cases and 1 047 cancer-free controls frequency matched by age and gender was conducted,and the genotypes were determined by the TaqMan assay.Logistic regression analysis was used to evaluate the odd ratios(ORs)and 95% confidence intervals(CIs)of rs1884444 T>G and rs6682925 T>C with susceptibility of esoph... |
| |
| Keywords: | IL23R polymorphism esophageal cancer susceptibility |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《南京医科大学学报(自然科学版)》浏览原始摘要信息 |
|
点击此处可从《南京医科大学学报(自然科学版)》下载全文 |
|
