| crp基因c+1444t多态性与中国苏皖地区汉族人群acs的易感性无关 |
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| 引用本文： | 何国平,戚 猛,高 磊,沈丹丹,金鸣锋,杨 笛,张寄南.crp基因c+1444t多态性与中国苏皖地区汉族人群acs的易感性无关[J].南京医科大学学报,2011(4):522-525. |
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| 作者姓名： | 何国平 戚 猛 高 磊 沈丹丹 金鸣锋 杨 笛 张寄南 |
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| 作者单位： | 江苏大学附属武进医院心内科;南京医科大学第一附属医院心血管病研究所; |
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| 基金项目： | 常州市科技计划项目[常科发(2009)90号] |
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| 摘 要： | 目的:探讨C反应蛋白(C-reactive portein,CRP)基因C+1444T多态性与急性冠脉综合征(acute coronary syndrome,ACS)的易感性。方法:选择2003年11月～2008年5月住院的ACS患者443例(ACS组)和同期经冠脉造影排除冠心病者285例(对照组),采用聚合酶链反应-限制性片段长度多态性(PCR-RELP)方法检测CRP基因C+1444T多态性。结果:ACS组的CC、CT和TT基因型以及C等位基因频率分布与对照组无显著性差异(83.7%vs 86.7%、14.4%vs 12.3%、1.8%vs 1.1%和91.0%vs 92.8%,P值分别为0.292、0.439、0.540和0.243)。调整年龄、性别、吸烟、收缩压、舒张压、血糖和血脂等多因素后采用多元Logistic回归分析显示,CRP基因C+1444T多态性与ACS的发生仍无显著性关联(P>0.05)。结论:在中国苏皖地区汉族人群中,CRP基因C+1444T多态性与ACS的易感性无显著相关性。
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| 关 键 词： | C反应蛋白 基因多态性 急性冠脉综合征 |
| 收稿时间： | 2010/10/6 0:00:00 |
no association of c-reaction protein gene c+1444t polymorphisms with acute coronary syndrome in chinese han population of suwan region |
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| he guo-ping,qi meng,gao lei,shen dan-dan,jin ming-feng,yang di and zhang ji-nan.no association of c-reaction protein gene c+1444t polymorphisms with acute coronary syndrome in chinese han population of suwan region[J].Acta Universitatis Medicinalis Nanjing,2011(4):522-525. |
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| Authors: | he guo-ping qi meng gao lei shen dan-dan jin ming-feng yang di and zhang ji-nan |
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| Institution: | HE Guo-ping*,QI Meng,GAO Lei,SHEN Dan-dan,JIN Ming-feng,YANG Di1,ZHANG Ji-nan1(Department of Cardiology,Affiliated Wujin Hospital of Jiangsu University,Changzhou 213002,1Institute of Cardiovascular Disease,the First Affiliated Hospital of NJMU,Nanjing 210029,China) |
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| Abstract: | Objective:To investigate the susceptibity of C-reaction protein(CRP) gene C+1444T polymorphisms to acute coronary syndrome(ACS).Methods:From Nov 2003 to May 2008,443 inpatients with ACS(ACS group) were recruited,the control group was consisted of 285 subjects who were free of coronary artery disease confirmed by coronary angiography.The CRP gene C+1444T polymorphisms were determined by polymerase chain reaction and restriction fragment length polymorphisms analysis.Results:There were no significant differen... |
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| Keywords: | C-reaction protein gene polymorphism acute coronary syndrome |
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