耐多药结核患者外周血CD4+CD25+Foxp3+T细胞的变化

目的:探讨CD4+CD25+Foxp3+T细胞在耐多药结核(multidrug-resistant TB,MDR-TB)发病机制中的作用。方法:随机选择MDR-TB患者31例,药物敏感性结核(drug-susceptible TB,S-TB)33例,健康对照(healthy control,HC)30例,流式细胞仪检测外周血CD4+CD25+Foxp3+T细胞。结果:S-TB患者外周血CD4+CD25+Foxp3+T细胞约占CD4+T细胞的(2.43±0.69)%,显著高于健康人的(1.61±0.46)%,两组之间差异具有显著统计学意义;MDR-TB患者外周血CD4+CD25+Foxp3+T细胞约占CD4+T细胞的(3.14±0.59)%,显著高于S-TB患者的细胞比例,两组之间差异具有显著统计学意义。结论:MDR-TB患者外周血CD4+CD25+Foxp3+T细胞明显增加,揭示其在MDR-TB发病中发挥了重要作用。

Change of the peripheral blood CD4+CD25+Foxp3+T cells in patients with multidrug-resistant tuberculosis

Objective:To observe the changes of CD4+CD25+Foxp3+T cells in patients with multidrug-resistant tuberchlosis(TB). Methods:We recruited 31 multidrug-resistant TB(MDR-TB) patients,33 drug-susceptible TB(S-TB) patients and 30 healthy controls. Flow cytometry was used to determined the quantity of CD4+CD25+Foxp3+T cells in the peripheral blood. Results:The mumber of CD4+CD25+Foxp3+T cell in the peripheral blood of patients with S-TB was(2.43±0.69)% of peripheral CD4+ T cell, it was significantly higher than heathy controls (1.61±0.46)%]and lower than patients with MDR-TB(3.14±0.59)%]. Conclusion:CD4+CD25+Foxp3+T cells increased in MDR-TB patients significantly, this suggests that CD4+CD25+Fox3+ T cells play an important role in the pathogenesis of MDR-TB.