Identification of distant co-evolving residues in antigen 85C from Mycobacterium tuberculosis using statistical coupling analysis of the esterase family proteins |
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Authors: | Veeky Baths Utpal Roy |
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Affiliation: | Veeky Baths*,Utpal Roy Department of Biological Sciences,BITS Pilani K. K Birla Goa Campus,GOA 403726,India. |
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Abstract: | A fundamental goal in cellular signaling is to understand allosteric communication, the process by which sig-nals originating at one site in a protein propagate reliably to affect distant functional sites. The general principles of protein structure that underlie this process remain unknown. Statistical coupling analysis (SCA) is a statistical technique that uses evolutionary data of a protein family to measure correlation between distant functional sites and suggests allosteric communication. In proteins, ... |
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Keywords: | antigen 85C Mycobacterium tuberculosis clustering analysis covariance statistical coupling analy-sis esterase family multiple sequence alignments pfam Protein Data Bank. |
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