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| 针刺对脑出血急性期大鼠脑损伤及脑水肿拮抗作用的机理研究 | |
| 引用本文： | 张国威,邹伟,刘芳,郭新年,赵佳辉,孙晓伟,李丹,王珑,滕伟,于学平,滕秀英,王迎新. 针刺对脑出血急性期大鼠脑损伤及脑水肿拮抗作用的机理研究[J]. 针灸临床杂志, 2010, 26(5) |
| 作者姓名： | 张国威 邹伟 刘芳 郭新年 赵佳辉 孙晓伟 李丹 王珑 滕伟 于学平 滕秀英 王迎新 |
| 作者单位： | 1. 内蒙古民族大学医学院,内蒙古,通辽,028000 2. 黑龙江中医药大学附属第一医院,黑龙江,哈尔滨,150040 3. 黑龙江省哈尔滨市第一医院,黑龙江,哈尔滨,150010 4. 黑龙江省康复医院,黑龙江,哈尔滨,150018 5. 黑龙江省中医研究院,黑龙江,哈尔滨,150036 |
| 基金项目： | 国家自然科学基金，哈尔滨市科技创新人才研究专项资金项目，黑龙江省教育厅科研项目，黑龙江省研究生创新科研基金 |
| 摘 要： | 目的:探讨针刺对脑出血急性期脑损伤及脑水肿拮抗作用的机理。方法:选取健康雄性W istar大鼠320只随机分为3组:模型组、针刺组、西药组,每组100只大鼠,每组再随机分为6 h、1 d、2 d、3 d、7 d共5个亚组,每个亚组20只大鼠;制备脑出血模型;另设20只正常大鼠作为空白组。针刺组针刺患侧"百会"透"曲鬓"穴。在光镜和电镜下观察各组大鼠脑组织形态学改变;应用干-湿重法测定各组大鼠脑水含量。结果:①针刺组较模型组神经细胞肿胀减轻,线粒体结构破坏较轻,突触结构较清晰。②干-湿重法结果显示,各造模组大鼠术后均出现不同程度的脑水肿现象。模型组大鼠术后6 h出现轻度脑水肿现象;3 d脑水肿达高峰;7 d仍有轻度脑水肿现象。针刺组较模型组和西药组脑水肿程度减轻,与模型组比较在1~7 d时差异明显(P0.01);与西药组比较在1~3 d时差异明显(P0.01)。结论:"百会"透"曲鬓"在脑出血急性期能明显减轻神经细胞损伤及超微结构的破坏、减少炎性细胞浸润、降低血肿周围脑组织脑水肿程度,提示对脑组织损伤及脑水肿有拮抗作用。 |
| 关 键 词： | “百会”透“曲鬓” 头针疗法 脑出血 脑损伤 脑水肿 拮抗作用 |
Experimental Study of the Mechanism of the Antagonism on Brain Injury and Encephaledema by Acupuncture Treatment on Rats of Acute Intercerebral Hemorrhage |
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| ZHANG Guo-wei,ZOU Wei,LIU Fang,GUO Xin-nian,ZHAO Jia-hui,SUN Xiao-wei,LI Dan,WANG Long,TENG Wei,YU Xue-ping,TENG Xiu-ying,WANG Ying-xin. Experimental Study of the Mechanism of the Antagonism on Brain Injury and Encephaledema by Acupuncture Treatment on Rats of Acute Intercerebral Hemorrhage[J]. Journal of Clinical Acupuncture and Moxibustion, 2010, 26(5) | |
| Authors: | ZHANG Guo-wei ZOU Wei LIU Fang GUO Xin-nian ZHAO Jia-hui SUN Xiao-wei LI Dan WANG Long TENG Wei YU Xue-ping TENG Xiu-ying WANG Ying-xin |
| Affiliation: | ZHANG Guo-wei1,ZOU Wei2,LIU Fang3,GUO Xin-nian4,ZHAO Jia-hui5,SUN Xiao-wei2,LI Dan2,WANG Long2,TENG Wei2,YU Xue-ping2,TENG Xiu-ying2,WANG Ying-xin2(1.Medical College,Inner Mongolia University for Nationalities,Tongliao 028000,China,2.The First Hospital Affiliated to Heilongjiang University of Chinese Medicine,Harbin 150040,3.Harbin First Hospital,Harbin 150010,4.The Heilongjiang Rehabilitation Hospital,Harbin 150018,5.Heilongjiang Academy of Chinese Medicine,Harbin 150036,China) |
| Abstract: | Objective:To research to the mechanism of the antagonism on brain injury and encephaledema in acute intracerebral hemorrhage by acupuncture.Methods:Selected the healthy Wistar male 320 rats by examination.The rats were assigned into 3 groups randomly: the model set,the pinprick set and the western medicine set,each group contained 100 rats.Each set were again divided into five subsets of 6 hours,1 day,2 days,3 days,7 days,and contained 20 rats in each.All rats were made to be the intracerebral hemorrhage mo... |
| Keywords: | BaiHui-QuBin Scalp-acupuncture Intracerebral Hemorrhage Brain Injury Encephaledema Antagonism |
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