大柴胡汤加味治疗高血压病合并焦虑的疗效观察

为观察大柴胡汤加味对高血压病合并焦虑的临床疗效,将符合纳入标准的126例高血压病合并焦虑患者随机分为治疗组64例和对照组62例。治疗组和对照组均给予苯磺酸氨氯地平片治疗,治疗组在基础西药治疗的基础上加服中药大柴胡汤加味,每日1剂,分2次服,每次100 mL,对照组给予氟哌噻吨美利曲辛片。疗程4周。观察治疗前后2组患者的血压、中医证候、血脂、C反应蛋白、汉密尔顿焦虑量表及不良反应。结果发现,在血压方面,与治疗前相比2组患者治疗后的血压均显著下降(P0.05),但组间比较无显著差异。在中医证候方面,治疗后两者比较有统计学差异(P0.05)。在血脂方面,与治疗前相比,治疗组的TC,TG,HDL-C,LDL-C差异有统计学意义(P0.05);与对照组相比,治疗后治疗组在TC上差异有统计学意义(P0.05)。在C反应蛋白方面,治疗组与对照组相比有显著下降(P0.05)。在焦虑症状方面,治疗组的汉密尔顿焦虑量表积分无统计学意义。在不良反应方面,2组患者均未见明显的不良反应。大柴胡汤加味治疗高血压病合并焦虑具有一定的临床疗效,在辅助降压的同时,还能改善中医证候,调节血脂、减轻炎症反应,改善焦虑,且安全性较好。

Clinical observation of modified Da Chaihu decoction in treating essential hypertension with anxiety

To observe the clinical efficacy of modified Da Chaihu decoction in treating essential hypertension with anxiety, the randomized, controlled, clinical trial was performed in this study. One hundred and twenty-six hypertensive patients with anxiety meeting the inclusive criteria were randomized into the treatment group and the control group. All of the included patients in the above 2 groups were treated by amlodipine besylate tablets. Patients in the treatment group were given Chinese herbal medicine modified Da Chaihu decoction every day. And patients in the control group were given flupentixol and melitracen tablets. The treatment course was 4 weeks. Blood pressure, the score of traditional Chinese medicine syndrome, blood lipids, C reactive protein, the Hamilton anxiety scale score and adverse effects were observed. It has been identified that, both systolic and diastolic blood pressure were significantly reduced (P< 0.05). However, no significant difference between the treatment group and the control group was identified. For traditional Chinese medicine syndrome, it was significantly improved in the treatment group (P< 0.05). For blood lipids, TC, TG, HDL-C, and LDL-C were significantly improved in the treatment group (P< 0.05). After treatment, only TC was significantly reduced in the treatment group when compared to the control group (P< 0.05). For C reactive protein, it was significantly reduced in the treatment group after treatment (P< 0.05). For anxiety, no significant difference between the treatment group and the control group on the Hamilton anxiety scale score was identified. For adverse effect, no severe adverse effect was identified in this study. The modified Da Chaihu decoction maybe effective in the treatment of essential hypertension with anxiety. In addition to a certain role in lowering blood pressure, the modified Da Chaihu decoction was also effective in improving traditional Chinese medicine syndrome and blood lipids, reducing the level of C reactive protein, relieving anxiety with little adverse effect.