| SIRT1基因的rs2273773和rs7895833突变与汉族人群冠状动脉疾病风险相关性分析 |
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| 引用本文： | 韩巧君,韩海荣,邹大进,连士杰,吴惠,徐洪涛. SIRT1基因的rs2273773和rs7895833突变与汉族人群冠状动脉疾病风险相关性分析[J]. 转化医学杂志, 2017, 6(3): 147-150 |
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| 作者姓名： | 韩巧君 韩海荣 邹大进 连士杰 吴惠 徐洪涛 |
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| 作者单位： | 海军总医院干部保健科,光华中西医结合医院,第二军医大学长海医院内分泌科,海军总医院干部保健科,海军总医院干部保健科,海军总医院干部保健科 |
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| 基金项目： | 海军后勤部科研课题（CHJ12L024） |
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| 摘 要： | 目的旨在调查汉族人群冠状动脉疾病患者SIRT1基因rs2273773和rs7895833的单核苷酸多态性。方法共纳入77例冠状动脉疾病患者和80例对照者。所有冠状动脉疾病患者通过血管造影术确诊。通过巢式聚合酶链反应测定SIRT1基因rs2273773和rs7895833多态性的基因分型。结果发现在中国汉族人群中，冠状动脉疾病患者和对照组SIRT1基因rs2273773和rs7895833的基因型频率差异无统计学意义（P>0.05）。本研究人群具有相比于发表的荷兰人群rs7895833的显著不同的等位基因频率。结论SIRT1基因遗传变异体rs2273773和rs7895833与中国汉族人群冠状动脉疾病无关。
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| 关 键 词： | 冠状动脉疾病；巢式聚合酶链反应；单核苷酸多态性；SIRT1基因 |
The relationship between the rs2273773 and rs7895833 mutations of SIRT1 gene and the risk of coronary artery disease among Han Chinese |
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| HAN Qiaojun,HAN Hairong,ZOU Dajin,LIAN Shijie,WU Hui and XU Hongtao. The relationship between the rs2273773 and rs7895833 mutations of SIRT1 gene and the risk of coronary artery disease among Han Chinese[J]. Translational Medicine Journal, 2017, 6(3): 147-150 |
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| Authors: | HAN Qiaojun HAN Hairong ZOU Dajin LIAN Shijie WU Hui XU Hongtao |
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| Affiliation: | Department of Cadre Health Care, Navy General Hospital, Beijing 100048, China,Department of Clinical Laboratory, Guanghua Chinese and Western Medicine Hospital, Shanghai 200052, China,Department of Endocrine, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China,Department of Cadre Health Care, Navy General Hospital, Beijing 100048, China,Department of Cadre Health Care, Navy General Hospital, Beijing 100048, China and Department of Cadre Health Care, Navy General Hospital, Beijing 100048, China |
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| Abstract: | ObjectiveTo investigate the single nucleotide polymorphisms rs2273773 and rs7895833 of SIRT1 gene in patients with coronary artery disease in the Han Chinese population. MethodsSeventy seven coronary artery disease patients and 80 controls were studied in the pre sent study. All coronary artery disease patients were confirmed by angiography. The genotyping of polymorphisms rs2273773 and rs7895833 in SIRT1 gene was determined by nested polymerase chain reaction. ResultsHowever, there was no significant difference in genotype frequencies between coronary artery disease patients and controls in the Chinese Han population. In addition, our study cohort has considerably differing allele frequencies of rs7895833 compared to the Dutch population. ConclusionThe rs2273773 and rs7895833 mutations of SIRT1 gene are not associated with the risk of coronary artery disease among Han Chinese. |
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| Keywords: | Coronary artery disease (CAD) Nested polymerase chain reaction (nPCR) Single nucleotide polymorphism (SNP) SIRT1 gene |
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