| 左旋咪唑诱导大鼠急性EAE外周血CD4+/CD8+和IL-6的检测及意义 |
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| 引用本文： | 郑和忠,余昌胤. 左旋咪唑诱导大鼠急性EAE外周血CD4+/CD8+和IL-6的检测及意义[J]. 中国实用神经疾病杂志, 2007, 10(1): 36-38 |
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| 作者姓名： | 郑和忠 余昌胤 |
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| 作者单位： | 宁波大学医学院附属阳明医院神经内科,余姚,315400;遵义医学院附属医院神经科,遵义,563003 |
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| 摘 要： | 目的 探讨急性实验性变态反应性脑脊髓炎(EAE)大鼠外周血CD4 /CD8 及IL-6的改变及意义.方法 采用豚鼠髓鞘蛋白匀浆和福氏完全佐剂注射并加用左旋咪唑诱发大鼠EAE模型,分别注射生理盐水/福氏佐剂、左旋咪唑作为对照,注射后16d采用Loyez氏髓鞘染色观察大鼠脊髓髓鞘改变、流式细胞仪检测外周血CD4 /CD8 比值和采用ELISA法检测IL-6水平,并与对照组比较.结果 模型组发病率87.5%,正常组、NS/CFA组和LMS对照组未见异常.模型组髓鞘染色见髓鞘结构疏松、部分髓鞘脱失;外周血CD4 /CD8 比值为2.33±1.04,及IL-6为194.92±56.85,较其余各组明显增高(P＜0.01,P＜0.01).结论 外周血CD4 /CD8 比值及IL-6水平增高在大鼠EAE的发生过程中发挥重要作用.
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| 关 键 词： | 脑脊髓炎 |
| 文章编号： | 1673-5110(2007)01-0036-03 |
| 修稿时间： | 2006-10-28 |
Assay of CD_4~ /CD_8~ and IL-6 in experimental allergic encephalomyelitis by levamisole and its clinical significance in Wistar rats. |
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| Zheng Hezhong,Yu Changyin. Assay of CD_4~ /CD_8~ and IL-6 in experimental allergic encephalomyelitis by levamisole and its clinical significance in Wistar rats.[J]. Chinese Journal of Practical Neruous Diseases, 2007, 10(1): 36-38 |
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| Authors: | Zheng Hezhong Yu Changyin |
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| Affiliation: | 1Department of Neurology, affiliated yangming hospital of NingBo Medical College, ZheJiang 315400;2 Department of Neurology, affiliated hospital of Zunyi Medical College, Zunyi 563003 |
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| Abstract: | |
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| Keywords: | Experimental allergic encephalomyelitis(EAE) |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
