165例急性白血病死亡原因回顾

目的:分析探讨165例急性白血病(非M3)的死因。方法:回顾165例急性白血病(非M3)死亡病例,总结急性白血病主要死亡原因及死亡时的疾病状态。结果:116例急性非淋巴细胞性白血病(非M3)的主要死因为感染(45.7%)和出血(28.4%),其次为中枢神经系统(8.6%)和肺部弥漫性损害(6.9%),44.0%病例死于疾病的复发阶段,28.4%在发病早期,25.0%在未缓解期内,仅2.6%死于完全缓解阶段。49例急性淋巴细胞性白血病的主要死因为感染(34.7%)、出血(30.6%)和浸润(26.5%),最常见的感染形式为败血症,出血和浸润最易累及的部位分别为颅内和中枢神经系统,多数病例死于疾病的早期(45.0%)和复发阶段(51.0%)。结论:感染、出血和浸润是急性白血病(非M3)的三大主要死因。

Cause of death in 165 cases of acute leukemia

Objective To review the causes of death in 165 patients with acute leukemia.Methods The clinical data from 165 patients with acute non-acute promyelocytic leukemia(APL) were retrospectively analysed.The major causes of death and the status of disease at death were summarized.Results The most common causes of death in 116 acute non-APL leukemia were infection(45.7%),hemorrhage(28.4%),diffused lung damage(6.9%) and central nervous system infiltration(8.6%).The most common stage at death was relapse stage(44.0%),followed by early stage(28.4%),non-remission stage(25.0%) and complete remission stage(2.6%).Concurrently,the most common causes of death in 49 acute lymphocytic leukemia were infection(34.7%),hemorrhage(30.6%) and infiltration(26.5%).The most common type of infection and hemorrhage was septicemia and intra-cranial bleeding,respectively.The central nervous system was the most easy-to-be-involved infiltration site.The most common stage at death was early stage(45.0%),followed by relapse stage(51.0%).Conclusions Infection,hemorrhage and infiltration are the three major causes of death in acute non-APL.