高血压病患者血浆氧自由基、纤溶活性、一氧化氮的变化及丹参粉针干预作用

目的 探讨高血压病患者氧自由基、纤溶活性、一氧化氮的变化及丹参粉针干预作用.方法 ①观察80例正常人和80例高血压病患者血浆丙二醛(MDA)、超氧化物歧化酶(SOD)、组织型血纤维蛋白溶酶原激活剂(t-PA),t-PA抑制物(PAⅠ)及一氧化氮(NO),并比较两组MDA、SOD、t-PA、PA Ⅰ及NO的变化；②80例高血压组随机分为对照组40例和观察组40例,对照组予左旋氨氯地平,观察组予左旋氨氯地平联合丹参粉针治疗,比较两组治疗前后MDA、SOD、t-PA、PA Ⅰ及NO的变化.结果 ①高血压组的MDA及PA Ⅰ较正常人组明显升高,而SOD、t-PA和NO较正常人组明显降低(P＜0.05).②对照组治疗前后MDA、SOD、t-PA、PA Ⅰ和NO的变化差异无统计学意义(P＞0.05),观察组治疗后MDA和PA Ⅰ较治疗前明显下降(P＜0.01),而SOD、t-PA、NO明显升高(P＜0.01).结论 高血压病患者存在MDA、SOD、t-PA、PA Ⅰ及NO异常,丹参粉针能提高患者的SOD活力,降低MDA含量,促进纤溶活性,NO合成释放增多.

Changes of oxygen-free radical,fibrinollytic activity and nitric oxide in plasma of the patients with hypertension and its interference by salvia miltiorrhiza bge

【Objective】 To investigate the change of oxygen-free radical,fibrinolytic activity and nitric oxide in plasma of the patients with hypertension and its interference by salvia miltiorrhiza bge(SMB).【Methods】 Malondialdehyde(MED),superoxide dismutase(SOD),tissue plasminogen avtivator(t-PA),plasminogen activator inhibitor(PAⅠ),nitric oxide(NO) were observed,then to be compared the variations of MDA,SOD,t-Pal,PAⅠ and NO in plasma of 80 cases of normal and 80 cases of hypertensive patients.80 cases of hypertensive patients were divided into observation group and control group randomly.Control group were treated with levamlodipine besylate and observation group were treated with combination levamlodipine besylate and SMB.And the variation of MDA,SOD,t-Pal,PAⅠ and NO before and after treatment in two groups were tinvestigated.【Results】 MDA and PAⅠ were significantly increased,but SOD,t-PA and NO were decreased in hypertensive patients than those in normal group.There were no significant difference in the variation of MDA,SOD,t-PA,PAⅠ and NO before and after treatment in control group(P >0.05).MDA and PAⅠ was significantly decreased(P <0.01),but SOD,t-PA,NO increased(P <0.01) after treatment than before treatment in observation group.【Conclusion】 There were abnormal of MDA,SOD,t-PA,PAⅠ and NO in plasma of the patients with hypertension.The SMB may enhance the SOD activity,reduce MDA content and promote fibrinollytic activity and increment of nitric oxide synthesis in plasma of the patients with hypertension.