地佐辛联合异丙酚在无痛胃肠镜检查术的应用

目的评价地佐辛联合异丙酚对无痛胃肠镜术的麻醉效果及安全性。方法收集接受无痛胃肠镜检查的患者共232例（胃肠镜136例，肠镜96例），随机分为观察组与对照组，后者单用异丙酚麻醉，观察组在异丙酚的基础上加用地佐辛。比较两组患者的生命体征、苏醒时间、异丙酚用量以及术后恶心感评分（VAS）等方面的差异。结果与对照组比较，术中观察组患者血压及心率显著低于对照组，而血氧饱和度高于对照组（P〈0．05）；观察组的异丙酚用量为（83．39±7．92）mg，显著少于对照组的（121．83±17．74）mg（t=-6．992，P=0．000）；观察组患者VAS评分明显低于对照组（f=1．782，P=0．036），但两组间的苏醒时间无统计学差异（P〉0．05）。结论地佐辛联合异丙酚应用于无痛胃肠镜的麻醉效果及血液动力学安全性优于单用异丙酚。

Effect of dezocine combined with propofol on patients undergoing painless gastrointestinal endoscopy

Objective To observe the effect of dezocine combined with propofol on patients undergoing painless gastrointestinal endoscopy.Methods A total of 232 subjects,including 136 patients undergoing gastric endoscopy and 96 patients undergoing colonic endoscopy.They were randomly divided into the observation and control group.Subjects in the control group were anaesthetized only by propofol,while the patients in the observation group were by both propofol and dezocine.Bblood pressure,heart rate,and SpO2 were compared between the two groups,so were the recovery time of consciousness,dose of propofol,and the visual analogue scale of nausea(VAS).Results Compared with the control group,the patients in the observation group presented significantly lower blood pressure and heart rate during gastrointestinal endoscopy,but significantly higher SPO2(P < 0.05).The mean dose of propofol in the observation group was(83.39 ± 7.92) mg which was significantly lower than(121.83 ± 17.74) mg in the control group(P < 0.05).Moreover,the VAS in the observation group was significantly less than those in the control group(P < 0.05),while the difference of recovery time of consciousness between the two groups was not statistically significant(P > 0.05).Conclusion Anesthetization with dezocine and propofol for patients undergoing painless gastrointestinal endoscopy is more effective and safer than with propofol alone.